1.1.1.254: (S)-carnitine 3-dehydrogenase

This is an abbreviated version, for detailed information about (S)-carnitine 3-dehydrogenase, go to the full flat file.

Reaction

(S)-carnitine
+
NAD+
=
3-dehydrocarnitine
+
NADH
+
H+

Synonyms

D(+)-carnitine dehydrogenase, D-carnitine dehydrogenase, dehydrogenase, D-carnitine

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.254 (S)-carnitine 3-dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.254 - (S)-carnitine 3-dehydrogenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5,5'-dithiobis(2-nitrobenzoate)
-
D-carnitine dehydrogenase, 1 mM, complete inactivation
Ag+
-
D-carnitine dehydrogenase, 1 mM, complete inactivation
Carnitine amide
-
competitive inhibitor of (S)-carnitine oxidation
cetyltrimethylammoniumbromide
-
D-carnitine dehydrogenase, higher than 5 mM, 10% of initial activity
choline
-
competitive inhibitor of (S)-carnitine oxidation; D-carnitine dehydrogenase, competitive inhibition
crotonobetaine
-
competitive inhibitor of (S)-carnitine oxidation; D-carnitine dehydrogenase, competitive inhibition
DL-beta-hydroxybutyrate
-
D-carnitine dehydrogenase, competitive inhibition
DL-carnitine amide
-
D-carnitine dehydrogenase, competitive inhibition
EDTA
-
; D-carnitine dehydrogenase, 20 mM, 25-70% inhibition
Fe2+
-
; D-carnitine dehydrogenase, 1 mM, 25-70% inhibition
gamma-butyrobetaine
-
competitive inhibitor of (S)-carnitine oxidation; D-carnitine dehydrogenase, competitive inhibition
glycine betaine
-
competitive inhibitor of (S)-carnitine oxidation; D-carnitine dehydrogenase, competitive inhibition
Hexadecyltrimethylammonium bromide
-
above 5 mM, 90% loss of activity
L(-)-carnitine
-
competitive inhibitor of (S)-carnitine oxidation
L-carnitine
-
D-carnitine dehydrogenase, strong competitive inhibition
N-ethylmaleimide
-
D-carnitine dehydrogenase, 1 mM, 77% inactivation after 3 min
p-chloromercuribenzoate
SDS
-
above 5 mM, 90% loss of activity; D-carnitine dehydrogenase, higher than 5 mM, 10% of initial activity