1.1.1.252: tetrahydroxynaphthalene reductase

This is an abbreviated version, for detailed information about tetrahydroxynaphthalene reductase, go to the full flat file.

Reaction

Scytalone
+
NADP+
=
1,3,6,8-Tetrahydroxynaphthalene
+
NADPH
+
H+

Synonyms

1,3,6,8-tetrahydroxynaphthalene reductase, 1,3,8-trihydroxynaphthalene reductase, 3HNR, 4HN, EC 1.3.1.50, hydroxynaphthalene reductase, NADPH-dependent naphthol reductase, naphthol reductase, reductase, naphthol, reductase, naphthol (Magnaporthe grisea clone pAV501 precursor reduced), T4HN reductase, T4HNR, tetrahydroxynaphthalene reductase (Magnaporthe grisea clone pAV501), THNR, trihydroxynaphthalene reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.252 tetrahydroxynaphthalene reductase

Substrates Products

Substrates Products on EC 1.1.1.252 - tetrahydroxynaphthalene reductase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Scytalone + NADP+
show the reaction diagram
1,3,6,8-tetrahydroxynaphthalene + NADPH + H+
scytalone + NADP+
show the reaction diagram
1,3,6-trihydroxynaphthalene + NADPH + H+
(R)-8-deoxyscytalone + NADP+
show the reaction diagram
-
-
-
-
?
1,3,8-trihydroxynaphthalene + NADPH + H+
vermelone + NADP+
show the reaction diagram
1,3-dihydroxynaphthalene + NADPH + H+
3-hydroxy-3,4-dihydronaphthalen-1(2H)-one + NADP+
show the reaction diagram
-
very low activity
-
-
?
1,4-androstadiene-3,17-dione + NADPH + H+
? + NADP+
show the reaction diagram
-
poor substrate of 3HNR
-
-
?
2,(5alpha)-androstene-17-one + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
?
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one + NAD+
?
show the reaction diagram
-
-
-
-
-
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one + NADP+
4,5-Dihydroxy-2H-benzopyran-2-one + NADPH
show the reaction diagram
2,3-dihydro-2,5-dihydroxy-4H-benzopyran-4-one + NADP+
4,5-dihydroxy-2H-benzopyran-2-one + NADPH + H+
show the reaction diagram
-
-
-
-
?
2-methylcyclohexanone + NADPH + H+
trans-2-methylcyclohexanol + NADP+
show the reaction diagram
-
-
-
-
?
2-tetralone + NADPH + H+
2-tetralol + NADP+
show the reaction diagram
-
high activity, almost complete conversion
-
-
?
4-androstene-3,17-dione + NADPH + H+
? + NADP+
show the reaction diagram
-
poor substrate of 3HNR
-
-
?
4-estrene-3,17-dione + NADPH + H+
? + NADP+
show the reaction diagram
-
poor substrate of 3HNR
-
-
?
5-androstene-3beta-ol-17-one + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
?
5-hydroxy-2-tetralone + NADPH + H+
5-hydroxy-2-tetralol + NADP+
show the reaction diagram
-
-
-
-
?
5-methoxy-2-tetralone + NADPH + H+
5-methoxy-2-tetralol + NADP+
show the reaction diagram
-
high activity, almost complete conversion
-
-
?
5alpha-androstane-3,17-dione + NADPH + H+
? + NADP+
show the reaction diagram
-
best steroid substrate for 3HNR
-
-
?
5alpha-androstane-3-one + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
?
5alpha-androstane-3alpha-ol-17-one + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
?
5alpha-androstane-3beta-ol-17-one + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
?
6-hydroxy-2-tetralone + NADPH + H+
6-hydroxy-2-tetralol + NADP+
show the reaction diagram
-
-
-
-
?
6-methoxy-2-tetralone + NADPH + H+
6-methoxy-2-tetralol + NADP+
show the reaction diagram
-
-
-
-
?
7-hydroxy-2-tetralone + NADPH + H+
7-hydroxy-2-tetralol + NADP+
show the reaction diagram
-
high activity, almost complete conversion
-
-
?
7-methoxy-2-tetralone + NADPH + H+
7-methoxy-2-tetralol + NADP+
show the reaction diagram
-
high activity, almost complete conversion
-
-
?
8-hydroxy-2-tetralone + NADPH + H+
8-hydroxy-2-tetralol + NADP+
show the reaction diagram
-
high activity, almost complete conversion
-
-
?
8-methoxy-2-tetralone + NADPH + H+
8-methoxy-2-tetralol + NADP+
show the reaction diagram
-
high activity, almost complete conversion
-
-
?
Phenanthrenequinone + NADPH
?
show the reaction diagram
-
-
-
-
-
additional information
?
-
-
no activity with estrone
-
-
-