1.1.1.252: tetrahydroxynaphthalene reductase

This is an abbreviated version, for detailed information about tetrahydroxynaphthalene reductase, go to the full flat file.

Reaction

Scytalone
+
NADP+
=
1,3,6,8-Tetrahydroxynaphthalene
+
NADPH
+
H+

Synonyms

1,3,6,8-tetrahydroxynaphthalene reductase, 1,3,8-trihydroxynaphthalene reductase, 3HNR, 4HN, EC 1.3.1.50, hydroxynaphthalene reductase, NADPH-dependent naphthol reductase, naphthol reductase, reductase, naphthol, reductase, naphthol (Magnaporthe grisea clone pAV501 precursor reduced), T4HN reductase, T4HNR, tetrahydroxynaphthalene reductase (Magnaporthe grisea clone pAV501), THNR, trihydroxynaphthalene reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.252 tetrahydroxynaphthalene reductase

Inhibitors

Inhibitors on EC 1.1.1.252 - tetrahydroxynaphthalene reductase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,3,8-Trihydroxynaphthalene
-
competitive to 1,3,6,8-tetrahydroxynaphthalene
1H-indene-1,3(2H)-dione
-
-
2,3,4,5,6-Pentachlorobenzyl alcohol
-
-
2,3-Dihydro-2,5-dihydroxy-4H-benzopyran-4-one
3,7-dihydroxyflavone
3-hydroxyflavone
5,7-dihydroxyflavone
5-hydroxyflavone
5-methoxyflavone
5-methyl-(1,2,4)-triazolo[3,4-b]benzothiazole
-
tricyclazole, specific inhibitor of 3HNR
6-hydroxyflavone
-
inhibits by 15%
7,4'-Dihydroxyflavone
-
inhibits by 51%
7-hydroxyflavone
-
inhibits by 9%
acacetin
-
inhibits by 90%
apigenin
baicalein
-
affects fungal pigmentation and growth, inhibits by 75%
Biochanin A
Chlobenthiazone
-
-
chrysoeriol
-
inhibits by 55%
diclofenac
-
-
diosmetin
-
inhibits by 83%
ethyl 6-methyl-4-oxo-4H-chromene-2-carboxylate
-
-
ethyl 6-methyl-8-nitro-4-oxo-4H-chromene-2-carboxylate
-
-
etodolac
-
-
fisetin
-
inhibits by 12%
flavanone
-
inhibits by 9%
flavone
-
inhibits by 38%
Fthalide
-
-
genistein
-
inhibits by 19%
genkwanin
-
inhibits by 28%
kaempferol
luteolin
myricetin
-
inhibits by 13%
N-Methyl-2-quinolone
-
weak
nabumetone
-
-
naringenin
pinostrobin
-
inhibits by 38%
Pyroquilon
-
-
quercetin
-
inhibits by 52%
s-Triazolo[4,3-a]-quinoline
-
weak
scutellarein
-
inhibits by 67%
Tricyclazole
additional information
-