1.1.1.252: tetrahydroxynaphthalene reductase

This is an abbreviated version, for detailed information about tetrahydroxynaphthalene reductase, go to the full flat file.

Reaction

Scytalone
+
NADP+
=
1,3,6,8-Tetrahydroxynaphthalene
+
NADPH
+
H+

Synonyms

1,3,6,8-tetrahydroxynaphthalene reductase, 1,3,8-trihydroxynaphthalene reductase, 3HNR, 4HN, EC 1.3.1.50, hydroxynaphthalene reductase, NADPH-dependent naphthol reductase, naphthol reductase, reductase, naphthol, reductase, naphthol (Magnaporthe grisea clone pAV501 precursor reduced), T4HN reductase, T4HNR, tetrahydroxynaphthalene reductase (Magnaporthe grisea clone pAV501), THNR, trihydroxynaphthalene reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.252 tetrahydroxynaphthalene reductase

General Information

General Information on EC 1.1.1.252 - tetrahydroxynaphthalene reductase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
-
the enzyme is a member of the short-chain dehydrogenase/reductase (SDR) family of enzymes
metabolism
-
the enzyme catalyzes a step in 1,8-dihydroxynaphthalene-melanin biosynthesis, overview
additional information
-
structure-activity relationship of T4HNR and dynamics of its catalytic cycle, substrate docking study, the carboxylate of Ile274 might have an impact on substrate orientation, overview. Two orientations of tetralones in the active site of T4HNR revealed by docking studies: 1. si-face orientation (representing the preferential hydrophobic interaction of the methoxy group of substrate 5-methoxy-2-tetralone) and 2. the re-face orientation