1.1.1.245: cyclohexanol dehydrogenase

This is an abbreviated version, for detailed information about cyclohexanol dehydrogenase, go to the full flat file.

Reaction

Cyclohexanol
+
NAD+
=
cyclohexanone
+
NADH
+
H+

Synonyms

alcohol dehydrogenase, cyclohexanol dehydrogenase II, dehydrogenase, cyclohexanol, SSADH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.245 cyclohexanol dehydrogenase

Cofactor

Cofactor on EC 1.1.1.245 - cyclohexanol dehydrogenase

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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADH
-
enzyme exhibits linearity of NAD(H) binding at pH 9.8 and at moderate ionic strength, in addition to positive cooperativity at pH 7.8 and 6.8, and at pH 9.8 in the presence of salt. NADH binding is positively cooperative below 20°C and negatively cooperative at 40–50°. Steady-state kinetic measurements show that SsADH displays standard Michaelis–Menten kinetics between 35°C and 45°C, but exhibits positive and negative cooperativity for NADH oxidation below and above this range of temperatures, respectively. Mutant N249Y displays non-cooperative behavious in coenzyme binding under the same experimental conditions used for the wild-type enzyme
NADP+