1.1.1.239: 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+), go to the full flat file.

Reaction

testosterone
+
NAD+
=
androstenedione
+
NADH
+
H+

Synonyms

17-ketoreductase, 17beta-HSD, 17beta-hydroxysteroid dehydrogenase type 5, 3alpha(17beta)-HSD, 3alpha(17beta)-hydroxysteroid dehydrogenase, AKR1C26, AKR1C27, AKR1C28, AKR1C3, AKR1C34, aldo-keto reductase 1C3, dehydrogenase, 3alpha,17beta-hydroxy steroid, More, NAD+-dependent 3alpha(17beta)-hydroxysteroid dehydrogenase, NAD+-dependent 3beta(17beta)-hydroxysteroid dehydrogenase, NAD+-linked S-tetralol dehydrogenase, PGER6, type 2 3alpha-HSD, type 2 3alpha-hxdroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 2 3alppha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 3 17beta-hydroxysteroid dehydrogenase, type 5 17beta-HSD, type 5 17beta-hydroxysteroid dehydrogenase, type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase, type 5 beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)

Turnover Number

Turnover Number on EC 1.1.1.239 - 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0075
(R)-1,2,3,4-tetrahydro-1-naphthol
pH 7.4, 25C, recombinant enzyme
0.042 - 0.367
(S)-1,2,3,4-tetrahydro-1-naphthol
0.039 - 0.4
(S)-1-indanol
0.183 - 0.98
(S)-camphorquinone
-
0.283
1-Acenaphthenol
pH 7.4, 25C, recombinant enzyme
0.155 - 0.45
1-phenyl-1,2-propanedione
0.157 - 0.867
16-oxoestrone
0.0063 - 0.0217
17beta-estradiol
0.118 - 0.55
2,3-Butanedione
0.028 - 0.16
2-Cyclohexen-1-ol
0.148
4-oxo-2-nonenal
-
pH 7.4, 25C
0.0014 - 0.012
4-pregnen-3alpha-ol-20-one
-
0.0052 - 0.065
5alpha-androstan-17beta-ol-3-one
0.45
5alpha-androstan-3alpha,17beta-diol
-
-
0.0033 - 0.058
5alpha-Androstan-3alpha-ol-17-one
0.0027 - 0.055
5alpha-androstane-3alpha,17beta-diol
0.267
5alpha-Pregnan-3alpha,21-diol-20-one
-
-
0.0012 - 0.0072
5alpha-pregnan-3alpha-ol-20-one
0.002 - 0.367
5beta-androstan-17beta-ol-3-one
0.167
5beta-androstan-3,17-dione
-
-
0.85
5beta-Androstan-3alpha,17beta-diol
-
-
0.0023 - 0.052
5beta-Androstan-3alpha-ol-17-one
0.004 - 0.0122
5beta-androstane-3alpha,17beta-diol
0.158
5beta-pregnan-3,20-dione
-
-
0.367
5beta-Pregnan-3alpha,21-diol-20-one
-
-
0.005 - 0.233
5beta-Pregnan-3alpha-ol-20-one
0.052 - 0.108
6-tert-butyl-2,3-epoxy-4-hydroxy-5-cyclohexen-1-one
0.152 - 0.617
9,10-phenanthrenequinone
0.04
alpha-3-hydroxyhexobarbital
pH 7.4, 25C, recombinant enzyme
-
0.0143 - 0.2
alpha-tetralone
0.088 - 0.29
benzene dihydrodiol
0.0967
beta-3-hydroxyhexobarbital
pH 7.4, 25C, recombinant enzyme
-
0.0075 - 0.053
beta-ionol
-
0.032
cis-benzene dihydrodiol
pH 7.4, 25C, recombinant enzyme
0.0011
estrone
-
pH 7.0, 37C
0.0045 - 0.027
farnesol
0.015 - 0.028
geraniol
0.0008 - 0.038
geranylgeraniol
0.02
glycochenodeoxycholic acid
-
-
0.25
glycolithocholic acid
-
-
0.183 - 0.65
isatin
0.00067 - 0.05
lithocholic acid
0.49
morphine
pH 7.4, 25C
0.004 - 0.283
NAD+
0.123 - 0.683
NADH
0.0917
NADP+
pH 7.4, 25C, with substrate S-camphorquinone
0.067
Naphthalene dihydrodiol
pH 7.4, 25C
0.115
nerol
pH 7.4, 25C, recombinant enzyme
0.025 - 0.2
Pyridine-3-aldehyde
0.0079 - 0.417
testosterone
0.045
trans-benzene dihydrodiol
pH 7.4, 25C, recombinant enzyme