1.1.1.239: 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+), go to the full flat file.

Reaction

testosterone
+
NAD+
=
androstenedione
+
NADH
+
H+

Synonyms

17-ketoreductase, 17beta-HSD, 17beta-hydroxysteroid dehydrogenase type 5, 3alpha(17beta)-HSD, 3alpha(17beta)-hydroxysteroid dehydrogenase, AKR1C26, AKR1C27, AKR1C28, AKR1C3, AKR1C34, aldo-keto reductase 1C3, dehydrogenase, 3alpha,17beta-hydroxy steroid, More, NAD+-dependent 3alpha(17beta)-hydroxysteroid dehydrogenase, NAD+-dependent 3beta(17beta)-hydroxysteroid dehydrogenase, NAD+-linked S-tetralol dehydrogenase, PGER6, type 2 3alpha-HSD, type 2 3alpha-hxdroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 2 3alppha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 3 17beta-hydroxysteroid dehydrogenase, type 5 17beta-HSD, type 5 17beta-hydroxysteroid dehydrogenase, type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase, type 5 beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)

KM Value

KM Value on EC 1.1.1.239 - 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.095
(R)-1,2,3,4-tetrahydro-1-naphthol
pH 7.4, 25°C, recombinant enzyme
0.004 - 0.25
(S)-1,2,3,4-tetrahydro-1-naphthol
0.014 - 0.181
(S)-1-indanol
0.0019 - 0.0067
(S)-camphorquinone
-
0.148
1-Acenaphthenol
pH 7.4, 25°C, recombinant enzyme
0.0008 - 0.005
1-phenyl-1,2-propanedione
0.0021 - 0.01
16-oxoestrone
0.0021 - 0.1
17beta-estradiol
0.19 - 0.371
2,3-Butanedione
0.035 - 0.67
2-Cyclohexen-1-ol
0.0031
4-oxo-2-nonenal
-
pH 7.4, 25°C
0.0057 - 0.081
4-pregnen-3alpha-ol-20-one
-
0.00067 - 0.13
5alpha-androstan-17beta-ol-3-one
0.0031
5alpha-androstan-3alpha,17beta-diol
-
-
0.0022 - 0.0092
5alpha-Androstan-3alpha-ol-17-one
0.0005 - 0.0078
5alpha-androstane-3alpha,17beta-diol
0.00067 - 0.0035
5alpha-pregnan-3alpha-ol-20-one
0.00067 - 0.03
5beta-androstan-17beta-ol-3-one
0.0066
5beta-androstan-3,17-dione
-
-
0.0048
5beta-Androstan-3alpha,17beta-diol
-
-
0.0015 - 0.0023
5beta-Androstan-3alpha-ol-17-one
0.0022 - 0.02
5beta-androstane-3alpha,17beta-diol
0.0038
5beta-pregnan-3,20-dione
-
-
0.0062
5beta-pregnan-3alpha,17beta-diol-20-one
-
-
0.0036 - 0.17
5beta-Pregnan-3alpha-ol-20-one
0.0021 - 0.101
6-tert-butyl-2,3-epoxy-4-hydroxy-5-cyclohexen-1-one
0.0001 - 0.0002
9,10-phenanthrenequinone
0.03
alpha-3-hydroxyhexobarbital
pH 7.4, 25°C, recombinant enzyme
-
0.0038 - 0.15
alpha-tetralone
0.0016
androst-4-ene-3,17-dione
-
-
0.024
androstendione
-
reduction of androstendione, pH 7.0
0.027 - 1.11
benzene dihydrodiol
0.013
beta-3-hydroxyhexobarbital
pH 7.4, 25°C, recombinant enzyme
-
0.0006 - 0.0097
beta-ionol
-
0.63
cis-benzene dihydrodiol
pH 7.4, 25°C, recombinant enzyme
0.009
estrone
-
pH 7.0, 37°C
0.00074 - 0.011
farnesol
0.0042 - 0.57
geraniol
0.0007 - 0.0012
geranylgeraniol
0.0075
glycochenodeoxycholic acid
-
-
0.003
glycolithocholic acid
-
-
0.0005 - 0.0011
isatin
0.0005 - 0.14
lithocholic acid
0.52
morphine
pH 7.4, 25°C
0.0068 - 0.27
NAD+
0.0026 - 0.033
NADH
1.38
NADP+
pH 7.4, 25°C, with substrate S-camphorquinone
0.027
Naphthalene dihydrodiol
pH 7.4, 25°C
0.162
nerol
pH 7.4, 25°C, recombinant enzyme
0.29 - 1.1
Pyridine-3-aldehyde
0.0016 - 0.25
testosterone
1
trans-benzene dihydrodiol
pH 7.4, 25°C, recombinant enzyme
additional information
additional information
-