1.1.1.239: 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)

This is an abbreviated version, for detailed information about 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+), go to the full flat file.

Reaction

testosterone
+
NAD+
=
androstenedione
+
NADH
+
H+

Synonyms

17-ketoreductase, 17beta-HSD, 17beta-hydroxysteroid dehydrogenase type 5, 3alpha(17beta)-HSD, 3alpha(17beta)-hydroxysteroid dehydrogenase, AKR1C26, AKR1C27, AKR1C28, AKR1C3, AKR1C34, aldo-keto reductase 1C3, dehydrogenase, 3alpha,17beta-hydroxy steroid, More, NAD+-dependent 3alpha(17beta)-hydroxysteroid dehydrogenase, NAD+-dependent 3beta(17beta)-hydroxysteroid dehydrogenase, NAD+-linked S-tetralol dehydrogenase, PGER6, type 2 3alpha-HSD, type 2 3alpha-hxdroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 2 3alppha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 3 17beta-hydroxysteroid dehydrogenase, type 5 17beta-HSD, type 5 17beta-hydroxysteroid dehydrogenase, type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase, type 5 beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)

KCat KM Value

KCat KM Value on EC 1.1.1.239 - 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.083
(R)-1,2,3,4-tetrahydro-1-naphthol
pH 7.4, 25C, recombinant enzyme
1.67
(S)-1,2,3,4-tetrahydro-1-naphthol
pH 7.4, 25C, recombinant enzyme
0.55
(S)-1-indanol
pH 7.4, 25C, recombinant enzyme
1.83
1-Acenaphthenol
pH 7.4, 25C, recombinant enzyme
0.05
2-Cyclohexen-1-ol
pH 7.4, 25C, recombinant enzyme
47.8
4-oxo-2-nonenal
-
pH 7.4, 25C
2.17
alpha-3-hydroxyhexobarbital
pH 7.4, 25C, recombinant enzyme
-
7.5
beta-3-hydroxyhexobarbital
pH 7.4, 25C, recombinant enzyme
-
5.3
beta-ionol
pH 7.4, 25C, recombinant enzyme
-
0.05
cis-benzene dihydrodiol
pH 7.4, 25C, recombinant enzyme
0.127
estrone
-
pH 7.0, 37C
0.42
farnesol
pH 7.4, 25C, recombinant enzyme
0.2
geraniol
pH 7.4, 25C, recombinant enzyme
33.3
geranylgeraniol
pH 7.4, 25C, recombinant enzyme
2
NAD+
pH 7.4, 25C, with substrate S-tetralol
12.67
NADH
pH 7.4, 25C, with substrate S-camphorquinone
0.067
NADP+
pH 7.4, 25C, with substrate S-camphorquinone
0.067
nerol
pH 7.4, 25C, recombinant enzyme
0.05
trans-benzene dihydrodiol
pH 7.4, 25C, recombinant enzyme