1.1.1.238: 12beta-hydroxysteroid dehydrogenase

This is an abbreviated version, for detailed information about 12beta-hydroxysteroid dehydrogenase, go to the full flat file.

Reaction

3alpha,7alpha,12beta-trihydroxy-5beta-cholan-24-oate
+
NADP+
=
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oate
+
NADPH
+
H+

Synonyms

12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.238 12beta-hydroxysteroid dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.238 - 12beta-hydroxysteroid dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3,12-dioxo-5beta-cholanoate + NADPH
12beta-hydroxy-3-oxo-5beta-cholanoate + NADP+
show the reaction diagram
-
-
-
?
3,7,12-trioxo-5beta-cholanoate + NADPH
12beta-hydroxy-3,7-dioxo-5beta-cholanoate + NADP+
show the reaction diagram
-
-
-
?
3,7,12-trioxotaureate + NADPH
12beta-hydroxy-3,7-dioxotaureate + NADP+
show the reaction diagram
-
-
-
?
3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanoate + NADPH
3alpha,7alpha,12beta-trihydroxy-5beta-cholanoate + NADP+
show the reaction diagram
-
-
-
?
3alpha-hydroxy-12-oxo-5beta-cholanoate + NADPH
3alpha,12beta-dihydroxy-5beta-cholanoate + NADP+
show the reaction diagram
-
reverse reaction 10% the rate of forward reaction
-
r
3alpha-hydroxy-7,12-dioxo-5beta-cholanoate + NADPH
3alpha,12beta-dihydroxy-7-oxo-5beta-cholanoate + NADP+
show the reaction diagram
-
-
-
?
7,12-dioxo-5beta-cholanoate + NADPH
12beta-hydroxy-7-oxo-5beta-cholanoate + NADP+
show the reaction diagram
-
-
-
?
7alpha-hydroxy-3,12-dioxo-5beta-cholanoate + NADPH
7alpha,12beta-dihydroxy-3-oxo-5beta-cholanoate + NADP+
show the reaction diagram
-
-
-
?