1.1.1.236: tropinone reductase II

This is an abbreviated version, for detailed information about tropinone reductase II, go to the full flat file.

Reaction

pseudotropine
+
NADP+
=
tropinone
+
NADPH
+
H+

Synonyms

More, pseudotropine forming tropinone reductase, pseudotropine-forming tropinone reductase, pseudotropinone forming tropinone reductase, TR-II, TRII, tropinone (psi-tropine-forming) reductase, tropinone reductase, tropinone reductase I, tropinone reductase II, tropinone reductase-II

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.236 tropinone reductase II

Reference

Reference on EC 1.1.1.236 - tropinone reductase II

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nakajima, K.; Kato, H.; Oda, J.; Yamada, Y.; Hashimoto, T.
Site-directed mutagenesis of putative substrate-binding residues reveals a mechanism controlling the different stereospecificities of two tropinone reductases
J. Biol. Chem.
274
16563-16568
1999
Arabidopsis sp., Datura stramonium, Hyoscyamus niger
Manually annotated by BRENDA team
Boswell, H.D.; Dräger, B.; McLauchlan W.R.; Portsteffen, A.; Robins D.J.; Robins R.J.; Walton, N.J.
Specificities of the enzymes of N-alkyltropane biosynthesis in Brugmansia and Datura
Phytochemistry
52
871-878
1999
Brugmansia x candida, Datura stramonium, Datura stramonium D15/5, Hyoscyamus niger
Manually annotated by BRENDA team
Draeger, B.; Hashimoto, T.; Yamada, Y.
Purification and characterization of pseudotropine forming tropinone reductase from Hyoscyamus niger root cultures
Agric. Biol. Chem.
52
2663-2667
1988
Datura stramonium, Hyoscyamus niger
-
Manually annotated by BRENDA team
Couladis, M.M.; Brent Friesen, J.; Landgrebe, M.E.; Leete, E.
Enzymes catalysing the reduction of tropinone to tropine and psi-tropine isolated from the roots of Datura innoxia
Phytochemistry
30
801-805
1991
Atropa belladonna, Datura inoxia, Datura stramonium, Hyoscyamus niger
-
Manually annotated by BRENDA team
Draeger, B.; Portsteffen, A.; Schaal, A.; McCabe, P.H.; Peerless, A.C.J.; Robins, R.J.
Levels of tropinone reductase activities influence the spectrum of tropane esters found in transformed root cultures of Daura stramonium L.
Planta
188
581-586
1992
Atropa belladonna, Datura inoxia, Datura stramonium, Hyoscyamus niger, Physalis peruviana
Manually annotated by BRENDA team
Hashimoto, T.; Nakajima, K.; Ongena, G.; Yamada, Y.
Two tropinone reductases with distinct stereospecificities from cultured roots of Hyoscyamus niger
Plant Physiol.
100
836-845
1992
Hyoscyamus niger
Manually annotated by BRENDA team
Portsteffen, A.; Draeger, B.; Nahrstedt, A.
Two tropinone reducing enzymes from Datura stramonium transformed root cultures
Phytochemistry
31
1135-1138
1992
Atropa belladonna, Calystegia sepium, Datura inoxia, Datura stramonium, Hyoscyamus bohemicus, Hyoscyamus canariensis, Hyoscyamus muticus, Hyoscyamus niger, Hyoscyamus pusillus, no activity in Brassica campestris, no activity in Browallia americana, no activity in Nicotiana tabacum, Physalis alkekengi, Physalis edulis, Physalis philadelphica, Physochlaina orientalis
-
Manually annotated by BRENDA team
Nakajima, K.; Hashimoto, T.; Yamada, Y.
Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor
Proc. Natl. Acad. Sci. USA
90
9591-9595
1993
Atropa belladonna, Datura stramonium, Hyoscyamus niger, no activity in Nicotiana tabacum
Manually annotated by BRENDA team
Portsteffen, A.; Draeger, B.; Nahrstedt, A.
The reduction of tropinone in Datura stramonium root cultures by two specific reductases
Phytochemistry
37
391-400
1994
Atropa belladonna, Datura stramonium
Manually annotated by BRENDA team
Nakajima, K.; Yamashita, A.; Akama, H.; Nakatsu, T.; Kato, H.; Hashimoto, T.; Oda, J.; Yamada, Y.
Crystal structures of two tropinone reductases: Different reaction stereospecificities in the same protein fold
Proc. Natl. Acad. Sci. USA
95
4876-4881
1998
Datura stramonium, Hyoscyamus niger
Manually annotated by BRENDA team
Nakajima, K.; Hashimoto, T.
Two tropinone reductases, that catalyze opposite stereospecific reductions in tropane alkaloid biosynthesis, are localized in plant root with different cell-specific patterns
Plant Cell Physiol.
40
1099-1107
1999
Atropa belladonna, Datura stramonium, Hyoscyamus niger, no activity in Nicotiana tabacum
Manually annotated by BRENDA team
Yamashita, A.; Kato, H.; Wakatsuki, S.; Tomizaki, T.; Nakatsu, T.; Nakajima, K.; Hashimoto, T.; Yamada, Y.; Oda, J.
Structure of tropinone reductase-II complexed with NADP+ and pseudotropine at 1.9 A resolution: implication for stereospecific substrate binding and catalysis
Biochemistry
38
7630-7637
1999
Datura stramonium (P50163)
Manually annotated by BRENDA team
Keiner, R.; Kaiser, H.; Nakajima, K.; Hashimoto, T.; Draeger, B.
Molecular cloning, expression and characterization of tropinone reductase II, an enzyme of the SDR family in Solanum tuberosum (L.)
Plant Mol. Biol.
48
299-308
2002
Atropa belladonna, Datura stramonium, Hyoscyamus niger, Solanum tuberosum
Manually annotated by BRENDA team
Yamashita, A.; Endo, M.; Higashi, T.; Nakatsu, T.; Yamada, Y.; Oda, J.; Kato, H.
Capturing enzyme structure prior to reaction initiation: tropinone reductase-II-substrate complexes
Biochemistry
42
5566-5573
2003
Datura stramonium (P50163)
Manually annotated by BRENDA team
Richter, U.; Rothe, G.; Fabian, A.K.; Rahfeld, B.; Drager, B.
Overexpression of tropinone reductases alters alkaloid composition in Atropa belladonna root cultures
J. Exp. Bot.
56
645-652
2005
Datura stramonium (P50163)
Manually annotated by BRENDA team
Draeger, B.
Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism
Phytochemistry
67
327-337
2006
Atropa belladonna, Datura stramonium, Hyoscyamus niger, Solanum tuberosum
Manually annotated by BRENDA team
Kaiser, H.; Richter, U.; Keiner, R.; Brabant, A.; Hause, B.; Draeger, B.
Immunolocalisation of two tropinone reductases in potato (Solanum tuberosum L.) root, stolon, and tuber sprouts
Planta
225
127-137
2006
Solanum tuberosum
Manually annotated by BRENDA team
Brock, A.; Brandt, W.; Draeger, B.
The functional divergence of short-chain dehydrogenases involved in tropinone reduction
Plant J.
54
388-401
2008
Cochlearia officinalis (A7DY56)
Manually annotated by BRENDA team
Freydank, A.C.; Brandt, W.; Draeger, B.
Protein structure modeling indicates hexahistidine-tag interference with enzyme activity
Proteins
72
173-183
2008
Solanum dulcamara
Manually annotated by BRENDA team
Kai, G.; Li, L.; Jiang, Y.; Yan, X.; Zhang, Y.; Lu, X.; Liao, P.; Chen, J.
Molecular cloning, characterization of two tropinone reductases in Anisodus acutangulus and enhancement of tropane alkaloids production in AaTRI-transformed hairy roots
Biotechnol. Appl. Biochem.
54
:177-186
2009
Anisodus acutangulus (B2L2W9)
Manually annotated by BRENDA team
Dehghan, E.; Shahriari Ahmadi, F.; Ghotbi Ravandi, E.; Reed, D.W.; Covello, P.S.; Bahrami, A.R.
An atypical pattern of accumulation of scopolamine and other tropane alkaloids and expression of alkaloid pathway genes in Hyoscyamus senecionis
Plant Physiol. Biochem.
70C
188-194
2013
Hyoscyamus muticus, Hyoscyamus senecionis
Manually annotated by BRENDA team