1.1.1.236: tropinone reductase II

This is an abbreviated version, for detailed information about tropinone reductase II, go to the full flat file.

Reaction

pseudotropine
+
NADP+
=
tropinone
+
NADPH
+
H+

Synonyms

More, pseudotropine forming tropinone reductase, pseudotropine-forming tropinone reductase, pseudotropinone forming tropinone reductase, TR-II, TRII, tropinone (psi-tropine-forming) reductase, tropinone reductase, tropinone reductase I, tropinone reductase II, tropinone reductase-II

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.236 tropinone reductase II

KM Value

KM Value on EC 1.1.1.236 - tropinone reductase II

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
7.58
3-methyl-cyclohexanone
-
-
7.58
3-methylcyclohexanone
-
-
0.534
4-ethyl-cyclohexanone
-
-
0.534
4-ethylcyclohexanone
-
-
2.03 - 2.8
4-methyl-cyclohexanone
2.03 - 2.8
4-methylcyclohexanone
21.6
4-Piperidone
-
-
0.38 - 2
4-tetrahydro-thiopyranone
0.67
N-(2-fluoroethyl)nortropinone
-
-
0.25
N-ethylnortropinone
-
-
0.65 - 20
N-methyl-4-piperidinone
0.057 - 0.77
N-Methyl-4-piperidone
1.4
N-methylpiperid-4-one
-
-
0.265
N-propyl-4-piperidinone
-
-
0.265 - 0.299
N-propylyl-4-piperidone
-
0.0076
NADH
-
-
0.251
NADP+
-
-
0.00172 - 0.0255
NADPH
0.025
Nortropinone
-
-
0.033 - 52.5
tropinone
additional information
additional information
-
the recombinant His-tagged enzyme shows an increased substrate affinity compared to the wild-type enzyme
-