1.1.1.231: 15-hydroxyprostaglandin-I dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about 15-hydroxyprostaglandin-I dehydrogenase (NADP+), go to the full flat file.

Reaction

(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate
+
NADP+
=
(5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
+
NADPH
+
H+

Synonyms

dehydrogenase, prostacyclin, NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase, NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase, PG I2 dehydrogenase, prostacyclin dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.231 15-hydroxyprostaglandin-I dehydrogenase (NADP+)

Substrates Products

Substrates Products on EC 1.1.1.231 - 15-hydroxyprostaglandin-I dehydrogenase (NADP+)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH
show the reaction diagram
4-benzoylpyridine + NADP+
?
show the reaction diagram
-
recombinant forms CHCR1, CHCR2
-
-
?
4-nitrobenzaldehyde + NADP+
4-nitrobenzoate + NADPH
show the reaction diagram
6-keto-prostaglandin F1alpha + NADP+
6,15-ketoprostaglandin F2alpha + NADPH
show the reaction diagram
-
at 1.8% the reaction rate of prostaglandin I2
-
-
?
menadione + NADP+
?
show the reaction diagram
-
more rapid reaction than with prostacyclin
-
-
?
phenanthrene quinone + NADP+
?
show the reaction diagram
-
more rapid reaction than with prostacyclin
-
-
?
prostaglandin B1 + NADP+
15-ketoprostaglandin B1 + NADPH + H+
show the reaction diagram
-
at 8% the reaction rate of prostaglandin I2
-
-
?
prostaglandin E2 + NADP+
15-ketoprostaglandin E2 + NADPH + H+
show the reaction diagram
prostaglandin F2alpha + NAD+
15-ketoprostaglandin F2alpha + NADH + H+
show the reaction diagram
-
-
-
-
?
prostaglandin F2alpha + NADP+
15-ketoprostaglandin F2alpha + NADPH + H+
show the reaction diagram
pyridine-4-carboxaldehyde + NADP+
?
show the reaction diagram
-
recombinant forms CHCR1, CHCR2
-
-
?
additional information
?
-