1.1.1.231: 15-hydroxyprostaglandin-I dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about 15-hydroxyprostaglandin-I dehydrogenase (NADP+), go to the full flat file.

Reaction

(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate
+
NADP+
=
(5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
+
NADPH
+
H+

Synonyms

dehydrogenase, prostacyclin, NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase, NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase, PG I2 dehydrogenase, prostacyclin dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.231 15-hydroxyprostaglandin-I dehydrogenase (NADP+)

Specific Activity

Specific Activity on EC 1.1.1.231 - 15-hydroxyprostaglandin-I dehydrogenase (NADP+)

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1.217
-
recombinant enzyme, latanoprost + NADP+
2.17
-
recombinant enzyme, acid form of latanoprost + NADP+
6.08
-
recombinant enzyme, prostaglandin F2alpha + NAD+
9.8
-
recombinant enzyme, prostaglandin E2 + NADP+
24.3
-
recombinant enzyme, prostaglandin F2alpha + NADP+
additional information
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