1.1.1.231: 15-hydroxyprostaglandin-I dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about 15-hydroxyprostaglandin-I dehydrogenase (NADP+), go to the full flat file.

Reaction

(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate
+
NADP+
=
(5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
+
NADPH
+
H+

Synonyms

dehydrogenase, prostacyclin, NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase, NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase, PG I2 dehydrogenase, prostacyclin dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.231 15-hydroxyprostaglandin-I dehydrogenase (NADP+)

Reference

Reference on EC 1.1.1.231 - 15-hydroxyprostaglandin-I dehydrogenase (NADP+)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Krook, M.; Ghosh, D.; Duax, W.; Jörnvall, H.
Three-dimensional model of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase and relationships to the NADP(+)-dependent enzyme (carbonyl reductase)
FEBS Lett.
322
139-142
1993
Homo sapiens
Manually annotated by BRENDA team
Korff, J.M.; Jarabak, J.
Isolation and properties of an NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase from rabbit kidney
Methods Enzymol.
86
152-155
1982
Oryctolagus cuniculus
Manually annotated by BRENDA team
Korff, J.M.; Jarabak, J.
The purification and characterization of a prostacyclin dehydrogenase from rabbit kidney
J. Biol. Chem.
257
2177-2181
1982
Oryctolagus cuniculus
Manually annotated by BRENDA team
Fujimori, K.; Okada, T.; Urade, Y.
Expression of NADP(+)-Dependent 15-Hydroxyprostaglandin Dehydrogenase mRNA in Monkey Ocular Tissues and Characterization of Its Recombinant Enzyme
J. Biochem.
131
383-389
2002
Macaca fascicularis
Manually annotated by BRENDA team
Terada, T.; Sugihara, Y.; Nakamura, K.; Sato, R.; Sakuma, S.; Fujimoto, Y.; Fujita, T.; Inazu, N.; Maeda, M.
Characterization of multiple Chinese hamster carbonyl reductases
Chem. Biol. Interact.
130-132
847-861
2001
Cricetulus griseus
Manually annotated by BRENDA team
Jarabak, J.; Luncsford, A.; Berkowitz, D.
Substrate specificity of three prostaglandin dehydrogenases
Prostaglandins
26
849-868
1983
Homo sapiens
Manually annotated by BRENDA team
Krook, M.; Ghosh, D.; Stromberg, R.; Carlquist, M.; Jornvall, H.
Carboxyethyllysine in a protein: Native carbonyl reductase/NADP+-dependent prostaglandin dehydrogenase
Proc. Natl. Acad. Sci. USA
90
502-506
1993
Homo sapiens
Manually annotated by BRENDA team