1.1.1.23: histidinol dehydrogenase

This is an abbreviated version, for detailed information about histidinol dehydrogenase, go to the full flat file.

Reaction

L-Histidinol
+ 2 NAD+ +
H2O
=
L-histidine
+ 2 NADH + 3 H+

Synonyms

BN980_GECA03s06082g, BsHDH, GcHDH, HDH, HIS4 protein, HisD, histidinol dehydrogenase, HLDase, L-histidinol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.23 histidinol dehydrogenase

Reference

Reference on EC 1.1.1.23 - histidinol dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Grubmeyer, C.; Teng, H.
Mechanism of Salmonella typhimurium histidinol dehydrogenase: kinetic isotope effects and pH profiles
Biochemistry
38
7355-7362
1999
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Kanaori, K.; Ohta, D.; Nosaka, A.Y.
Effect of excess cadmium ion on the metal binding site of cabbage histidinol dehydrogenase studie by 113Cd-NMR spectroscopy
FEBS Lett.
412
301-304
1997
Brassica oleracea
Manually annotated by BRENDA team
Kheirolomoom, A.; Mano, J.; Nagai, A.; Ogawa, A.; Iwasaki, G.; Ohta, D.
Steady-state kinetics of cabbage histidinol dehydrogenase
Arch. Biochem. Biophys.
312
493-500
1994
Brassica oleracea
Manually annotated by BRENDA team
Nagai, A.; Ohta, D.
Histidinol dehydrogenase loses its catalytic function through the mutation of His261-Asn due to its inability to ligate the essential Zn
J. Biochem.
115
22-25
1994
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Nagai, A.; Kheirolomoom, A.; Ohta, D.
Site-directed mutagenesis shows that the conserved cysteine residues of histidinol dehydrogensae are not essential for catalysis
J. Biochem.
114
856-861
1993
Brassica oleracea
Manually annotated by BRENDA team
Nagai, A.; Suzuku, K.; Ward, E.; Moyer, M.; Hashimoto, M.; Mano, J.; Ohta, D.; Scheidegger, A.
Overexpression of plant histidinol dehydrogenase using baculovirus expression vector system
Arch. Biochem. Biophys.
295
235-239
1992
Brassica oleracea
Manually annotated by BRENDA team
Nagai, A.; Ward, E.; Beck, J.; Tada, S.; Chang, J.; Scheidegger, A.
Structural and functional conservation of histidinol dehydrogenase between plants and microbes
Proc. Natl. Acad. Sci. USA
88
4133-4137
1991
Brassica oleracea
Manually annotated by BRENDA team
Nagai, A.; Scheidegger, A.
Purification and characterization of histidinol dehydrogenase from cabbage
Arch. Biochem. Biophys.
284
127-132
1991
Asparagus officinalis, Brassica oleracea, Brassica oleracea var. capitata, Cucumis sativus, Lactuca sativa, Rosa sp., Solanum melongena, Triticum aestivum
Manually annotated by BRENDA team
Grubmeyer, C.T.; Gray, W.R.
A cysteine residue (cysteine-116) in the histidinol binding site of histidinoldehydrogenase
Biochemistry
25
4778-4784
1986
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Görisch, H.; Hölke, W.
Binding of histidinal to histidinol dehydrogenase
Eur. J. Biochem.
150
305-308
1985
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Andorn, N.; Aronovitch, J.
Purification and properties of histidinol dehydrogenase from Escherichia coli B
J. Gen. Microbiol.
128
579-584
1982
Escherichia coli
Manually annotated by BRENDA team
Feingold, D.S.; Franzen, J.S.
Pyridine nucleotide-linked four-electron transfer dehydrogenases
Trends Biochem. Sci.
6
103-105
1981
Salmonella enterica subsp. enterica serovar Typhimurium
-
Manually annotated by BRENDA team
Burger, E.; Görisch, H.
Evidence for an essential lysine at the active site of L-histidinol:NAD+ oxidoreductase; a bifunctional dehydrogenase
Eur. J. Biochem.
118
125-130
1981
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Burger, E.; Görisch, H.; Lingens,
The catalytically active form of histidinol dehydrogenase from Salmonella typhimurium
Biochem. J.
181
771-774
1979
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Bitar, K.G.; Firca, J.R.; Loper, J.C.
Histidinol dehydrogenase from salmonella typhimurium and escherichia coli. Purification, some characteristics and the amino acid sequence around a reactive thiol group
Biochim. Biophys. Acta
493
429-440
1977
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Lindsay, J.A.; Creaser, E.H.
Purification and properties of histidinol dehydrogenases from psychrophilic, mesophilic and thermophilic bacilli
Biochem. J.
165
247-253
1977
Bacillus caldolyticus, Bacillus subtilis, Bacillus subtilis HT1, Geobacillus stearothermophilus, Sporosarcina psychrophila
Manually annotated by BRENDA team
Yang, H.J.; Lee, B.; Haslam, J.L.
Studies on histidinol dehydrogenase preliminary crystallographic data
J. Mol. Biol.
81
517-519
1973
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Loper, J.C.; Adams, E.
Purification and properties of histidinol dehydrogenase from Salmonella typhimurium
J. Biol. Chem.
240
788-795
1965
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Adams, E.
The enzymatic synthesis of histidine from histidinol
J. Biol. Chem.
209
829-846
1954
Escherichia coli, Paenarthrobacter histidinolovorans
Manually annotated by BRENDA team
Wadud, S.; Or-Rashid, M.M.; Onodera, R.
Method for determination of histidine in tissues by isocratic high-performance liquid chromatography and its application to the measurement of histidinol dehydrogenase activity in six cattle organs
J. Chromatogr. B
767
369-374
2002
Bos taurus
Manually annotated by BRENDA team
Barbosa, J.A.; Sivaraman, J.; Li, Y.; Larocque, R.; Matte, A.; Schrag, J.D.; Cygler, M.
Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase
Proc. Natl. Acad. Sci. USA
99
1859-1864
2002
Escherichia coli, Escherichia coli (P06988)
Manually annotated by BRENDA team
Joseph, P.; Abdo, M.R.; Boigegrain, R.A.; Montero, J.L.; Winum, J.Y.; Koehler, S.
Targeting of the Brucella suis virulence factor histidinol dehydrogenase by histidinol analogues results in inhibition of intramacrophagic multiplication of the pathogen
Antimicrob. Agents Chemother.
51
3752-3755
2007
Brucella suis
Manually annotated by BRENDA team
Abdo, M.R.; Joseph, P.; Boigegrain, R.A.; Montero, J.L.; Kohler, S.; Winum, J.Y.
Brucella suis histidinol dehydrogenase: Synthesis and inhibition studies of substituted N-L-histidinylphenylsulfonyl hydrazide
J. Enzyme Inhib. Med. Chem.
23
357-361
2008
Brucella suis
Manually annotated by BRENDA team
Pahwa, S.; Chavan, A.G.; Jain, R.; Roy, N.
Target-specific anti-fungal discovery by targeting Geotrichum candidum histidinol dehydrogenase: a hybrid approach
Chem. Biol. Drug Des.
72
229-234
2008
Geotrichum candidum
Manually annotated by BRENDA team
Pahwa, S.; Kaur, S.; Jain, R.; Roy, N.
Structure based design of novel inhibitors for histidinol dehydrogenase from Geotrichum candidum
Bioorg. Med. Chem. Lett.
20
3972-3976
2010
Geotrichum candidum (A1BPP9), Geotrichum candidum
Manually annotated by BRENDA team
Nunes, J.E.; Ducati, R.G.; Breda, A.; Rosado, L.A.; de Souza, B.M.; Palma, M.S.; Santos, D.S.; Basso, L.A.
Molecular, kinetic, thermodynamic, and structural analyses of Mycobacterium tuberculosis hisD-encoded metal-dependent dimeric histidinol dehydrogenase (EC 1.1.1.23)
Arch. Biochem. Biophys.
512
143-153
2011
Mycobacterium tuberculosis (I6Y6Z1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (I6Y6Z1)
Manually annotated by BRENDA team
Turtaut, F.; Ouahrani-Bettache, S.; Montero, J.; Köhler, S.; Winum, J.
Synthesis and biological evaluation of a new class of anti-brucella compounds targeting histidinol dehydrogenase: alpha-O-arylketones and alpha-S-arylketones derived from histidine
MedChemComm
2
995-1000
2011
Brucella sp.
-
Manually annotated by BRENDA team
Abdo, M.R.; Joseph, P.; Mortier, J.; Turtaut, F.; Montero, J.L.; Masereel, B.; Koehler, S.; Winum, J.Y.
Anti-virulence strategy against Brucella suis: synthesis, biological evaluation and molecular modeling of selective histidinol dehydrogenase inhibitors
Org. Biomol. Chem.
9
3681-3690
2011
Brucella suis
Manually annotated by BRENDA team
D'Ambrosio, K.; Lopez, M.; Dathan, N.A.; Ouahrani-Bettache, S.; Koehler, S.; Ascione, G.; Monti, S.M.; Winum, J.Y.; De Simone, G.
Structural basis for the rational design of new anti-Brucella agents: the crystal structure of the C366S mutant of L-histidinol dehydrogenase from Brucella suis
Biochimie
97
114-120
2014
Brucella suis bv. 1 1330 (Q8G2R2), Brucella suis bv. 1 (Q8G2R2)
Manually annotated by BRENDA team
Turtaut, F.; Lopez, M.; Ouahrani-Bettache, S.; Koehler, S.; Winum, J.Y.
Oxo- and thiooxo-imidazo[1,5-c]pyrimidine molecule library: beyond their interest in inhibition of Brucella suis histidinol dehydrogenase, a powerful protection tool in the synthesis of histidine analogues
Bioorg. Med. Chem. Lett.
24
5008-5010
2014
Brucella suis
Manually annotated by BRENDA team
Lunardi, J.; Borges Martinelli, L.; Raupp, A.; Sacconi Nunes, J.; Rostirolla, D.; Saraiva Macdo Timmers, L.; Villela, A.; Pissinate, K.; Limberger, J.; Norberto De Souza, O.; Basso, L.; Santos, D.; Machado, P.
Mycobacterium tuberculosis histidinol dehydrogenase: Biochemical characterization and inhibition studies
RSC Adv.
6
28406-28418
2016
Mycobacterium tuberculosis (P9WNW9), Mycobacterium tuberculosis H37Rv (P9WNW9)
-
Manually annotated by BRENDA team
Koehler, S.; Dessolin, J.; Winum, J.
Inhibitors of histidinol dehydrogenase
Top. Med. Chem.
22
35-46
2017
Brassica oleracea (P24226), Brucella sp., Brucella suis (Q8G2R2), Brucella suis 1330 (Q8G2R2), Burkholderia pseudomallei (Q63Q86), Burkholderia pseudomallei K96243 (Q63Q86), Escherichia coli (P06988), Geotrichum candidum (A0A0J9X7D2), Mycobacterium tuberculosis (P9WNW9), Mycobacterium tuberculosis H37Rv (P9WNW9), Salmonella enterica subsp. enterica serovar Typhimurium (P10370), Salmonella enterica subsp. enterica serovar Typhimurium LT2 (P10370)
-
Manually annotated by BRENDA team