1.1.1.23: histidinol dehydrogenase

This is an abbreviated version, for detailed information about histidinol dehydrogenase, go to the full flat file.

Reaction

L-Histidinol
+ 2 NAD+ +
H2O
=
L-histidine
+ 2 NADH + 3 H+

Synonyms

GcHDH, HDH, HIS4 protein, HisD, histidinol dehydrogenase, HLDase, L-histidinol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.23 histidinol dehydrogenase

Reference

Reference on EC 1.1.1.23 - histidinol dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Grubmeyer, C.; Teng, H.
Mechanism of Salmonella typhimurium histidinol dehydrogenase: kinetic isotope effects and pH profiles
Biochemistry
38
7355-7362
1999
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Kanaori, K.; Ohta, D.; Nosaka, A.Y.
Effect of excess cadmium ion on the metal binding site of cabbage histidinol dehydrogenase studie by 113Cd-NMR spectroscopy
FEBS Lett.
412
301-304
1997
Brassica oleracea
Manually annotated by BRENDA team
Kheirolomoom, A.; Mano, J.; Nagai, A.; Ogawa, A.; Iwasaki, G.; Ohta, D.
Steady-state kinetics of cabbage histidinol dehydrogenase
Arch. Biochem. Biophys.
312
493-500
1994
Brassica oleracea
Manually annotated by BRENDA team
Nagai, A.; Ohta, D.
Histidinol dehydrogenase loses its catalytic function through the mutation of His261-Asn due to its inability to ligate the essential Zn
J. Biochem.
115
22-25
1994
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Nagai, A.; Kheirolomoom, A.; Ohta, D.
Site-directed mutagenesis shows that the conserved cysteine residues of histidinol dehydrogensae are not essential for catalysis
J. Biochem.
114
856-861
1993
Brassica oleracea
Manually annotated by BRENDA team
Nagai, A.; Suzuku, K.; Ward, E.; Moyer, M.; Hashimoto, M.; Mano, J.; Ohta, D.; Scheidegger, A.
Overexpression of plant histidinol dehydrogenase using baculovirus expression vector system
Arch. Biochem. Biophys.
295
235-239
1992
Brassica oleracea
Manually annotated by BRENDA team
Nagai, A.; Ward, E.; Beck, J.; Tada, S.; Chang, J.; Scheidegger, A.
Structural and functional conservation of histidinol dehydrogenase between plants and microbes
Proc. Natl. Acad. Sci. USA
88
4133-4137
1991
Brassica oleracea
Manually annotated by BRENDA team
Nagai, A.; Scheidegger, A.
Purification and characterization of histidinol dehydrogenase from cabbage
Arch. Biochem. Biophys.
284
127-132
1991
Asparagus officinalis, Brassica oleracea, Brassica oleracea var. capitata, Cucumis sativus, Lactuca sativa, Rosa sp., Solanum melongena, Triticum aestivum
Manually annotated by BRENDA team
Grubmeyer, C.T.; Gray, W.R.
A cysteine residue (cysteine-116) in the histidinol binding site of histidinoldehydrogenase
Biochemistry
25
4778-4784
1986
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Görisch, H.; Hölke, W.
Binding of histidinal to histidinol dehydrogenase
Eur. J. Biochem.
150
305-308
1985
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Andorn, N.; Aronovitch, J.
Purification and properties of histidinol dehydrogenase from Escherichia coli B
J. Gen. Microbiol.
128
579-584
1982
Escherichia coli
Manually annotated by BRENDA team
Feingold, D.S.; Franzen, J.S.
Pyridine nucleotide-linked four-electron transfer dehydrogenases
Trends Biochem. Sci.
6
103-105
1981
Salmonella enterica subsp. enterica serovar Typhimurium
-
Manually annotated by BRENDA team
Burger, E.; Görisch, H.
Evidence for an essential lysine at the active site of L-histidinol:NAD+ oxidoreductase; a bifunctional dehydrogenase
Eur. J. Biochem.
118
125-130
1981
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Burger, E.; Görisch, H.; Lingens,
The catalytically active form of histidinol dehydrogenase from Salmonella typhimurium
Biochem. J.
181
771-774
1979
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Bitar, K.G.; Firca, J.R.; Loper, J.C.
Histidinol dehydrogenase from salmonella typhimurium and escherichia coli. Purification, some characteristics and the amino acid sequence around a reactive thiol group
Biochim. Biophys. Acta
493
429-440
1977
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Lindsay, J.A.; Creaser, E.H.
Purification and properties of histidinol dehydrogenases from psychrophilic, mesophilic and thermophilic bacilli
Biochem. J.
165
247-253
1977
Bacillus caldolyticus, Bacillus subtilis, Bacillus subtilis HT1, Geobacillus stearothermophilus, Sporosarcina psychrophila
Manually annotated by BRENDA team
Yang, H.J.; Lee, B.; Haslam, J.L.
Studies on histidinol dehydrogenase preliminary crystallographic data
J. Mol. Biol.
81
517-519
1973
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Loper, J.C.; Adams, E.
Purification and properties of histidinol dehydrogenase from Salmonella typhimurium
J. Biol. Chem.
240
788-795
1965
Salmonella enterica subsp. enterica serovar Typhimurium
Manually annotated by BRENDA team
Adams, E.
The enzymatic synthesis of histidine from histidinol
J. Biol. Chem.
209
829-846
1954
Escherichia coli, Paenarthrobacter histidinolovorans
Manually annotated by BRENDA team
Wadud, S.; Or-Rashid, M.M.; Onodera, R.
Method for determination of histidine in tissues by isocratic high-performance liquid chromatography and its application to the measurement of histidinol dehydrogenase activity in six cattle organs
J. Chromatogr. B
767
369-374
2002
Bos taurus
Manually annotated by BRENDA team
Barbosa, J.A.; Sivaraman, J.; Li, Y.; Larocque, R.; Matte, A.; Schrag, J.D.; Cygler, M.
Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase
Proc. Natl. Acad. Sci. USA
99
1859-1864
2002
Escherichia coli, Escherichia coli (P06988)
Manually annotated by BRENDA team
Joseph, P.; Abdo, M.R.; Boigegrain, R.A.; Montero, J.L.; Winum, J.Y.; Koehler, S.
Targeting of the Brucella suis virulence factor histidinol dehydrogenase by histidinol analogues results in inhibition of intramacrophagic multiplication of the pathogen
Antimicrob. Agents Chemother.
51
3752-3755
2007
Brucella suis
Manually annotated by BRENDA team
Abdo, M.R.; Joseph, P.; Boigegrain, R.A.; Montero, J.L.; Kohler, S.; Winum, J.Y.
Brucella suis histidinol dehydrogenase: Synthesis and inhibition studies of substituted N-L-histidinylphenylsulfonyl hydrazide
J. Enzyme Inhib. Med. Chem.
23
357-361
2008
Brucella suis
Manually annotated by BRENDA team
Pahwa, S.; Chavan, A.G.; Jain, R.; Roy, N.
Target-specific anti-fungal discovery by targeting Geotrichum candidum histidinol dehydrogenase: a hybrid approach
Chem. Biol. Drug Des.
72
229-234
2008
Geotrichum candidum
Manually annotated by BRENDA team
Pahwa, S.; Kaur, S.; Jain, R.; Roy, N.
Structure based design of novel inhibitors for histidinol dehydrogenase from Geotrichum candidum
Bioorg. Med. Chem. Lett.
20
3972-3976
2010
Geotrichum candidum (A1BPP9), Geotrichum candidum
Manually annotated by BRENDA team
Nunes, J.E.; Ducati, R.G.; Breda, A.; Rosado, L.A.; de Souza, B.M.; Palma, M.S.; Santos, D.S.; Basso, L.A.
Molecular, kinetic, thermodynamic, and structural analyses of Mycobacterium tuberculosis hisD-encoded metal-dependent dimeric histidinol dehydrogenase (EC 1.1.1.23)
Arch. Biochem. Biophys.
512
143-153
2011
Mycobacterium tuberculosis (I6Y6Z1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (I6Y6Z1)
Manually annotated by BRENDA team
Turtaut, F.; Ouahrani-Bettache, S.; Montero, J.; Köhler, S.; Winum, J.
Synthesis and biological evaluation of a new class of anti-brucella compounds targeting histidinol dehydrogenase: alpha-O-arylketones and alpha-S-arylketones derived from histidine
MedChemComm
2
995-1000
2011
Brucella sp.
-
Manually annotated by BRENDA team
Abdo, M.R.; Joseph, P.; Mortier, J.; Turtaut, F.; Montero, J.L.; Masereel, B.; Koehler, S.; Winum, J.Y.
Anti-virulence strategy against Brucella suis: synthesis, biological evaluation and molecular modeling of selective histidinol dehydrogenase inhibitors
Org. Biomol. Chem.
9
3681-3690
2011
Brucella suis
Manually annotated by BRENDA team