1.1.1.23: histidinol dehydrogenase

This is an abbreviated version, for detailed information about histidinol dehydrogenase, go to the full flat file.

Reaction

L-Histidinol
+ 2 NAD+ +
H2O
=
L-histidine
+ 2 NADH + 3 H+

Synonyms

BN980_GECA03s06082g, BsHDH, GcHDH, HDH, HIS4 protein, HisD, histidinol dehydrogenase, HLDase, L-histidinol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.23 histidinol dehydrogenase

IC50 Value

IC50 Value on EC 1.1.1.23 - histidinol dehydrogenase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.14
(2S)-2-amino-3-(1H-imidazol-4-yl)-N'-(naphthalen-2-ylsulfonyl)propanehydrazide
Brucella suis
-
pH 9.2, 30°C
0.16
(2S)-2-amino-3-(1H-imidazol-4-yl)-N'-[(4-methylphenyl)sulfonyl]propanehydrazide
Brucella suis
-
pH 9.2, 30°C
0.025
(2S)-2-amino-N'-(biphenyl-4-ylsulfonyl)-3-(1H-imidazol-4-yl)propanehydrazide
0.07
(2S)-2-amino-N'-[(4-bromophenyl)sulfonyl]-3-(1H-imidazol-4-yl)propanehydrazide
Brucella suis
-
pH 9.2, 30°C
0.0028
(3S)-3-amino-1-(2,3,4,5,6-pentafluorophenyloxy)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride
Brucella sp.
-
pH 9.2, 30°C, recombinant His6-tagged enzyme
0.0192
(3S)-3-amino-1-(2,3,4,5,6-pentafluorophenylthio)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride
Brucella sp.
-
pH 9.2, 30°C, recombinant His6-tagged enzyme
0.01
(3S)-3-amino-1-(2,4-difluorophenyl)-4-(1H-imidazol-4-yl)butan-2-one
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.19
0.0016
(3S)-3-amino-1-(4-bromophenoxy)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride
Brucella sp.
-
pH 9.2, 30°C, recombinant His6-tagged enzyme
0.006
(3S)-3-amino-1-(4-bromophenyl)-4-(1H-imidazol-4-yl)butan-2-one
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.16
0.0028
(3S)-3-amino-1-(4-bromophenylthio)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride
Brucella sp.
-
pH 9.2, 30°C, recombinant His6-tagged enzyme
0.012
(3S)-3-amino-1-(4-chlorophenyl)-4-(1H-imidazol-4-yl)butan-2-one
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.17
0.0047
(3S)-3-amino-1-(4-fluorophenoxy)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride
Brucella sp.
-
pH 9.2, 30°C, recombinant His6-tagged enzyme
0.0031
(3S)-3-amino-1-(4-fluorophenylthio)-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride
Brucella sp.
-
pH 9.2, 30°C, recombinant His6-tagged enzyme
0.00004
(3S)-3-amino-1-(4-hydroxyphenyl)-4-(1H-imidazol-4-yl)butan-2-one
Brassica oleracea
P24226
pH and temperature not specified in the publication
0.012
(3S)-3-amino-1-([1,1'-biphenyl]-4-yl)-4-(1H-imidazol-4-yl)butan-2-one
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.20
0.000024
(3S)-3-amino-1-hydroxy-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride
Brucella sp.
-
pH 9.2, 30°C, recombinant His6-tagged enzyme
0.0021
(3S)-3-amino-1-thio-4-(1H-imidazol-4-yl)butan-2-one dihydrochloride
Brucella sp.
-
pH 9.2, 30°C, recombinant His6-tagged enzyme
0.000003 - 3
(3S)-3-amino-1-[4-(benzyloxy)phenyl]-4-(1H-imidazol-4-yl)butan-2-one
40
(3S)-3-amino-1-[4-[(4-butylbenzyl)oxy]phenyl]-4-(1H-imidazol-4-yl)butan-2-one
Brucella suis
-
pH and temperature not specified in the publication
65
(3S)-3-amino-1-[4-[(4-tert-butylphenyl)ethynyl]phenyl]-4-(1H-imidazol-4-yl)butan-2-one
Brucella suis
-
pH and temperature not specified in the publication
0.015
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(4-methylphenyl)butan-2-one
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.18
65
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(4-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]phenyl)butan-2-one
Brucella suis
-
pH and temperature not specified in the publication
30
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(4-[[4-(naphthalen-2-yl)benzyl]oxy]phenyl)butan-2-one
Brucella suis
-
pH and temperature not specified in the publication
30
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(4-[[4-(trifluoromethyl)benzyl]oxy]phenyl)butan-2-one
Brucella suis
-
pH and temperature not specified in the publication
0.00011
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(naphthalen-2-yloxy)butan-2-one dihydrochloride
Brucella sp.
-
pH 9.2, 30°C, recombinant His6-tagged enzyme
0.0033
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(naphthalen-2-ylthio)butan-2-one dihydrochloride
Brucella sp.
-
pH 9.2, 30°C, recombinant His6-tagged enzyme
0.00021
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(p-tolyloxy)butan-2-one dihydrochloride
Brucella sp.
-
pH 9.2, 30°C, recombinant His6-tagged enzyme
0.0037
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(phenyloxy)butan-2-one dihydrochloride
Brucella sp.
-
pH 9.2, 30°C, recombinant His6-tagged enzyme
0.0071
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(phenylthio)butan-2-one dihydrochloride
Brucella sp.
-
pH 9.2, 30°C, recombinant His6-tagged enzyme
0.0395
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-(tolylthio)butan-2-one dihydrochloride
Brucella sp.
-
pH 9.2, 30°C, recombinant His6-tagged enzyme
0.001
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-phenylbutan-2-one
Escherichia coli
-
pH and temperature not specified in the publication
13
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-(2-phenylethyl)phenyl]butan-2-one
Brucella suis
-
pH and temperature not specified in the publication
0.009
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-(7-phenylhept-1-yn-1-yl)phenyl]butan-2-one
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.21
3
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-(phenylethynyl)phenyl]butan-2-one
Brucella suis
-
pH and temperature not specified in the publication
30
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(1E)-3-phenylprop-1-en-1-yl]phenyl]butan-2-one
Brucella suis
-
pH and temperature not specified in the publication
20
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-methoxybenzyl)oxy]phenyl]butan-2-one
Brucella suis
-
pH and temperature not specified in the publication
30
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-methylbenzyl)oxy]phenyl]butan-2-one
Brucella suis
-
pH and temperature not specified in the publication
40
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-methylphenyl)ethynyl]phenyl]butan-2-one
Brucella suis
-
pH and temperature not specified in the publication
8.5
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-pentylphenyl)ethynyl]phenyl]butan-2-one
Brucella suis
-
pH and temperature not specified in the publication
70
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(4-phenoxybenzyl)oxy]phenyl]butan-2-one
Brucella suis
-
pH and temperature not specified in the publication
40
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(E)-2-(4-methylphenyl)ethenyl]phenyl]butan-2-one
Brucella suis
-
pH and temperature not specified in the publication
25
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[(E)-2-phenylethenyl]phenyl]butan-2-one
Brucella suis
-
pH and temperature not specified in the publication
0.000003 - 0.00007
(3S)-3-amino-4-(1H-imidazol-4-yl)-1-[4-[4-(phenylethynyl)benzyl]phenyl]butan-2-one
0.005
(3S)-3-amino-4-(1H-imidazol-4-yl)butan-2-one
Salmonella enterica subsp. enterica serovar Typhimurium
P10370
pH and temperature not specified in the publication
0.0587
(7R)-1,3-diiodo-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid
Galactomyces candidum
-
-
0.143
(7S)-7-[(2,4-difluorophenyl)acetyl]-7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.6
0.098
(7S)-7-[(4-bromophenyl)acetyl]-7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.3
0.092
(7S)-7-[(4-chlorophenyl)acetyl]-7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.4
0.113
(7S)-7-[(4-methylphenyl)acetyl]-7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.5
0.086
(7S)-7-[([1,1'-biphenyl]-4-yl)acetyl]-7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.7
0.175
(7S)-7-[[4-(7-phenylhept-1-yn-1-yl)phenyl]acetyl]-7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.8
0.005
(8S)-8-[2-(biphenyl-4-yl)ethanethioyl]-7,8-dihydroimidazo[1,5-c]pyrimidine-5(6H)-thione
Mycobacterium tuberculosis
-
pH and temperature not specified in the publication
0.000003
(S)-3-amino-1-(4-(benzyloxy)phenyl)-4-(1H-imidazol-4-yl)butan-2-one
Brucella suis
-
pH 9.2, 30°C
0.000006
(S)-3-amino-1-(4-bromophenyl)-4-(1H-imidazol-4-yl)butan-2-one
Brucella suis
-
pH 9.2, 30°C
0.000012
(S)-3-amino-1-(4-chlorophenyl)-4-(1H-imidazol-4-yl)butan-2-one
Brucella suis
-
pH 9.2, 30°C
0.000015
(S)-3-amino-1-(4-fluorophenyl)-4-(1H-imidazol-4-yl)butan-2-one
Brucella suis
-
pH 9.2, 30°C
0.000016
(S)-3-amino-4-(1H-imidazol-4-yl)-1-(4-phenoxyphenyl)butan-2-one
Brucella suis
-
pH 9.2, 30°C
0.0000145
(S)-3-amino-4-(1H-imidazol-4-yl)-1-(naphthalen-2-yl)butan-2-one
Brucella suis
-
pH 9.2, 30°C
0.000015
(S)-3-amino-4-(1H-imidazol-4-yl)-1-p-tolylbutan-2-one
Brucella suis
-
pH 9.2, 30°C
0.0587
1,3-diiodo-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid
Galactomyces candidum
A1BPP9
pH not specified in the publication, temperature not specified in the publication
0.095
2-(2,4-difluorophenyl)-1-[(7S)-5-sulfanylidene-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidin-7-yl]ethan-1-one
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.13
0.105
2-(4-bromophenyl)-1-[(7S)-5-sulfanylidene-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidin-7-yl]ethan-1-one
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.10
0.074
2-(4-chlorophenyl)-1-[(7S)-5-sulfanylidene-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidin-7-yl]ethan-1-one
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.11
0.095
2-(4-methylphenyl)-1-[(7S)-5-sulfanylidene-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidin-7-yl]ethan-1-one
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.12
0.005
2-([1,1'-biphenyl]-4-yl)-1-[(7S)-5-sulfanylidene-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidin-7-yl]ethan-1-one
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.14
0.005
2-amino-3-(1H-imidazol-4-yl)-N'-[(E)-(4-methoxyphenyl)methylidene]propanehydrazide
Mycobacterium tuberculosis
-
pH 7.2, 25°C
0.0055
2-amino-3-(1H-imidazol-4-yl)-N'-[(E)-(4-methylphenyl)methylidene]propanehydrazide
Mycobacterium tuberculosis
-
pH 7.2, 25°C
0.0025
2-amino-3-(1H-imidazol-4-yl)-N'-[(E)-(4-nitrophenyl)methylidene]propanehydrazide
Mycobacterium tuberculosis
-
pH 7.2, 25°C
0.0098
2-amino-3-(1H-imidazol-4-yl)-N'-[(E)-(4-phenoxyphenyl)methylidene]propanehydrazide
Mycobacterium tuberculosis
-
pH 7.2, 25°C
0.0011
2-amino-3-(1H-imidazol-4-yl)-N'-[(E)-(naphthalen-2-yl)methylidene]propanehydrazide
Mycobacterium tuberculosis
-
pH 7.2, 25°C
0.029
2-amino-3-(1H-imidazol-4-yl)-N'-[(E)-phenylmethylidene]propanehydrazide (non-preferred name)
Mycobacterium tuberculosis
-
pH 7.2, 25°C
0.027
2-amino-N'-[(E)-(2-hydroxyphenyl)methylidene]-3-(1H-imidazol-4-yl)propanehydrazide
Mycobacterium tuberculosis
-
pH 7.2, 25°C
0.0077
2-amino-N'-[(E)-(4-bromophenyl)methylidene]-3-(1H-imidazol-4-yl)propanehydrazide
Mycobacterium tuberculosis
-
pH 7.2, 25°C
0.0024
2-amino-N'-[(E)-(4-chlorophenyl)methylidene]-3-(1H-imidazol-4-yl)propanehydrazide
Mycobacterium tuberculosis
-
pH 7.2, 25°C
0.0024
2-amino-N'-[(E)-(4-fluorophenyl)methylidene]-3-(1H-imidazol-4-yl)propanehydrazide
Mycobacterium tuberculosis
-
pH 7.2, 25°C
0.0091
2-amino-N'-[(E)-[4-(dimethylamino)phenyl]methylidene]-3-(1H-imidazol-4-yl)propanehydrazide
Mycobacterium tuberculosis
-
pH 7.2, 25°C
0.322
2-[4-(7-phenylhept-1-yn-1-yl)phenyl]-1-[(7S)-5-sulfanylidene-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidin-7-yl]ethan-1-one
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.15
0.00317
3-(1H-imidazol-4-yl)propanoic acid
Galactomyces candidum
A1BPP9
pH not specified in the publication, temperature not specified in the publication
0.00356
5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid
Galactomyces candidum
A1BPP9
pH not specified in the publication, temperature not specified in the publication
0.0242
7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one
0.0064
imidazole-4-carboxylic acid
Galactomyces candidum
-
-
0.1222
methyl (7R)-1-chloro-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate
Galactomyces candidum
-
-
0.532
methyl (7S)-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.2
0.018
methyl (7S)-5-sulfanylidene-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate
Brucella suis
-
at 30°C in the presence of 0.05 mM histidinol, 2 mM NAD+ and 0.5 mM MnCl2 in 150 mM sodium glycine buffer at pH 9.9
0.1222
methyl 1-chloro-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate
Galactomyces candidum
A1BPP9
pH not specified in the publication, temperature not specified in the publication
0.0293
methyl 1-methyl-N-(phenoxycarbonyl)histidinate
Galactomyces candidum
A1BPP9
pH not specified in the publication, temperature not specified in the publication
0.0052
methyl 3-(1H-imidazol-4-yl)propanoate
0.0293
methyl N-(ethoxycarbonyl)-1-methyl-L-histidinate
Galactomyces candidum
-
-
0.0106
methyl N-(methoxycarbonyl)-3-methyl-L-histidinate
Galactomyces candidum
-
-
0.0106
methyl N-(methoxycarbonyl)histidinate
Galactomyces candidum
A1BPP9
pH not specified in the publication, temperature not specified in the publication