1.1.1.23: histidinol dehydrogenase

This is an abbreviated version, for detailed information about histidinol dehydrogenase, go to the full flat file.

Reaction

L-Histidinol
+ 2 NAD+ +
H2O
=
L-histidine
+ 2 NADH + 3 H+

Synonyms

GcHDH, HDH, HIS4 protein, HisD, histidinol dehydrogenase, HLDase, L-histidinol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.23 histidinol dehydrogenase

Engineering

Engineering on EC 1.1.1.23 - histidinol dehydrogenase

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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C112A
-
conserved Cys-112 is not involved in catalysis, Cys-112 corresponds to Cys-116 in Salmonella typhimurium
H261N
-
mutation causes complete loss of Zn and activity