1.1.1.220: 6-pyruvoyltetrahydropterin 2'-reductase

This is an abbreviated version, for detailed information about 6-pyruvoyltetrahydropterin 2'-reductase, go to the full flat file.

Reaction

6-Lactoyl-5,6,7,8-tetrahydropterin
+
NADP+
=
6-pyruvoyltetrahydropterin
+
NADPH
+
H+

Synonyms

6-pyruvoyl tetrahydropterin (2'-oxo)reductase, 6-pyruvoyl-tetrahydropterin 2'-reductase, 6-pyruvoyltetrahydropterin reductase, 6PPH4(2'-oxo) reductase, pyruvoyl-tetrahydropterin reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.220 6-pyruvoyltetrahydropterin 2'-reductase

Reference

Reference on EC 1.1.1.220 - 6-pyruvoyltetrahydropterin 2'-reductase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Milstien, S.; Kaufman, S.
Biosynthesis of tetrahydrobiopterin: conversion of dihydroneopterin triphosphate to tetrahydropterin intermediates
Biochem. Biophys. Res. Commun.
128
1099-1107
1985
Bos taurus, Rattus norvegicus
Manually annotated by BRENDA team
Milstien, S.; Kaufman, S.
The biosynthesis of tetrahydrobiopterin in rat brain. Purification and characterization of 6-pyruvoyl tetrahydropterin (2-oxo)reductase
J. Biol. Chem.
264
8066-8073
1989
Rattus norvegicus
Manually annotated by BRENDA team
Steinerstauch, P.; Wermuth, B.; Leimbacher, W.; Curtius, H.C.
Human liver 6-pyruvoyl tetrahydropterin reductase is biochemically and immunologically indistinguishable from aldose reductase
Biochem. Biophys. Res. Commun.
164
1130-1136
1989
Homo sapiens
Manually annotated by BRENDA team