1.1.1.22: UDP-glucose 6-dehydrogenase

This is an abbreviated version, for detailed information about UDP-glucose 6-dehydrogenase, go to the full flat file.

Reaction

UDP-alpha-D-glucose
+ 2 NAD+ +
H2O
=
UDP-alpha-D-glucuronate
+ 2 NADH + 2 H+

Synonyms

ADH-like UDP-glucose dehydrogenase, AglM, BceC, dehydrogenase, uridine diphosphoglucose, dual specificity UDP-glucose dehydrogenase, HasB, HasB2, HVO_1531, PA2022, PA3559, sqv-4, Sugarless protein, UDP-alpha-D-glucose:NAD oxidoreductase, UDP-D-glucose dehydrogenase, UDP-GDH, UDP-Glc dehydrogenase, UDP-Glc DH, UDP-GlcDH, UDP-GlcDHase, UDP-glucose dehydrogenase, UDPDH, UDPG dehydrogenase, UDPG-DH, UDPG:NAD oxidoreductase, UDPGD, UDPGDH, UDPGDH-A, UDPGDH-B, UDPGlc dehydrogenase, UDPglucose dehydrogenase, UDPglucose:NAD+ oxidoreductase, Ugd, UGD1, UgdG, UGDH, uridine diphosphate D-glucose dehydrogenase, uridine diphosphate glucose dehydrogenase, uridine diphosphate glucose-6-dehydrogenase, uridine diphosphate-glucose dehydrogenase, uridine diphosphoglucose dehydrogenase, uridine-5'-diphosphoglucose dehydrogenase, uridyl phosphate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.22 UDP-glucose 6-dehydrogenase

Specific Activity

Specific Activity on EC 1.1.1.22 - UDP-glucose 6-dehydrogenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000031
-
mutant D280N, pH 7.4, 22C
0.00022
-
mutant K276A, pH 7.4, 22C
0.0004
-
mutant K220H, pH 7.4, 22C
0.00041
-
mutant K220R, pH 7.4, 22C
0.00051
-
lysates of cells treated with 0.3 mM gallic acid
0.00061
-
lysates of cells treated with 0.3 mM quercetin
0.0015
-
control lysates
0.00247
-
mutant K279A, pH 7.4, 22C
0.0027
-
mutant K276S, pH 7.4, 22C
0.0029
-
mutant K220A, pH 7.4, 22C
0.41
-
mutant D280E, pH 7.4, 22C
0.69
-
wild-type, 22C, pH 7.4
0.74
-
mutant K339A, pH 7.4, 22C
1.5
-
recombinant and purified
2.17
Saccharum spp.
-
pH 8.4, 25C
27.17
-
purified 390fold
342.9
-
pH 8.8, 25C
additional information