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1.1.1.22: UDP-glucose 6-dehydrogenase

This is an abbreviated version!
For detailed information about UDP-glucose 6-dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.22

Reaction

UDP-alpha-D-glucose
+ 2 NAD+ +
H2O
=
UDP-alpha-D-glucuronate
+ 2 NADH + 2 H+

Synonyms

ADH-like UDP-glucose dehydrogenase, AglM, BceC, Cj1441c, dehydrogenase, uridine diphosphoglucose, dual specificity UDP-glucose dehydrogenase, GbUGD, GH_D12G1806, HasB, HasB2, HVO_1531, jekyll m151, kfiD, PA2022, PA3559, PH02Gene21682, sqv-4, Sugarless protein, UDG1, UDP-alpha-D-glucose:NAD oxidoreductase, UDP-D-glucose dehydrogenase, UDP-GDH, UDP-Glc dehydrogenase, UDP-Glc DH, UDP-GlcDH, UDP-GlcDHase, UDP-glucose dehydrogenase, UDPDH, UDPG dehydrogenase, UDPG-DH, UDPG:NAD oxidoreductase, UDPGD, UDPGDH, UDPGDH-A, UDPGDH-B, UDPGlc dehydrogenase, UDPglucose dehydrogenase, UDPglucose:NAD+ oxidoreductase, Ugd, UGD1, Ugd2, UgdG, UGDH, UGDH4, uridine diphosphate D-glucose dehydrogenase, uridine diphosphate glucose dehydrogenase, uridine diphosphate glucose-6-dehydrogenase, uridine diphosphate-glucose dehydrogenase, uridine diphosphoglucose dehydrogenase, uridine-5'-diphosphoglucose dehydrogenase, uridyl phosphate dehydrogenase, VNG1048G, VNG_1048G

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.22 UDP-glucose 6-dehydrogenase

Disease

Disease on EC 1.1.1.22 - UDP-glucose 6-dehydrogenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Arthritis, Rheumatoid
Quantitative histochemical study of hyaluronic acid binding protein and the activity of uridine diphosphoglucose dehydrogenase in the synovium of patients with rheumatoid arthritis.
The synovial proteome: analysis of fibroblast-like synoviocytes.
Uridine diphosphoglucose dehydrogenase activity in synovial lining cells in the experimental antigen induced model of rheumatoid arthritis: an indication of synovial lining cell function.
Brain Diseases
Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy.
Breast Neoplasms
Correction: UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression.
Identification and cloning of a novel androgen-responsive gene, uridine diphosphoglucose dehydrogenase, in human breast cancer cells.
Identification and Cloning of a Novel Androgen-Responsive Gene, Uridine Diphosphoglucose Dehydrogenase, in Human Breast Cancer Cells1.
Inhibition of Human UDP-Glucose Dehydrogenase Expression Using siRNA Expression Vector in Breast Cancer Cells
Inhibition of human UDP-glucose dehydrogenase expression using siRNA expression vector in breast cancer cells.
Initial Identification of UDP-Glucose Dehydrogenase as a Prognostic Marker in Breast Cancer Patients, Which Facilitates Epirubicin Resistance and Regulates Hyaluronan Synthesis in MDA-MB-231 Cells.
UDP-glucose 6-dehydrogenase knockout impairs migration and decreases in vivo metastatic ability of breast cancer cells.
UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression.
Colorectal Neoplasms
Down-regulation of UDP-glucose dehydrogenase affects glycosaminoglycans synthesis and motility in HCT-8 colorectal carcinoma cells.
Granuloma
[Adrenocortical hormones and biosynthesis of acid mucopolysaccharides. II. UDPG:NAD oxidoreductase activity in the subcutaneous granuloma of adrenalectomized rats treated with cortisone, corticosterone and aldosterone]
Granulomatous Disease, Chronic
Discovery and Biochemical Characterization of UDP-Glucose Dehydrogenase from Granulibacter bethesdensis.
Graves Disease
Divergent Sp1 protein levels may underlie differential expression of UDP-glucose dehydrogenase by fibroblasts: role in susceptibility to orbital Graves disease.
Liver Neoplasms
Biochemical and histochemical properties of hepatic tumors of rainbow trout, Oncorhynchus mykiss.
Neoplasm Metastasis
Targeting UDP-glucose dehydrogenase inhibits ovarian cancer growth and metastasis.
Neoplasms
Uridine diphosphoglucose dehydrogenase of mast cell tumours.
Osteoarthritis
UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis.
Ovarian Neoplasms
Targeting UDP-glucose dehydrogenase inhibits ovarian cancer growth and metastasis.
Periodontitis
[UDP-glucose dehydrogenase and beta-glucuronidase activities in the gingival tissue of dogs with experimental periodontitis (author's transl)]
Prostatic Neoplasms
UDP-glucose dehydrogenase as a novel field-specific candidate biomarker of prostate cancer.
Rheumatoid Nodule
Palisading cells of rheumatoid nodules: comparison with synovial intimal cells.