1.1.1.22: UDP-glucose 6-dehydrogenase

This is an abbreviated version, for detailed information about UDP-glucose 6-dehydrogenase, go to the full flat file.

Reaction

UDP-alpha-D-glucose
+ 2 NAD+ +
H2O
=
UDP-alpha-D-glucuronate
+ 2 NADH + 2 H+

Synonyms

ADH-like UDP-glucose dehydrogenase, AglM, BceC, dehydrogenase, uridine diphosphoglucose, dual specificity UDP-glucose dehydrogenase, HasB, HasB2, HVO_1531, PA2022, PA3559, sqv-4, Sugarless protein, UDP-alpha-D-glucose:NAD oxidoreductase, UDP-D-glucose dehydrogenase, UDP-GDH, UDP-Glc dehydrogenase, UDP-Glc DH, UDP-GlcDH, UDP-GlcDHase, UDP-glucose dehydrogenase, UDPDH, UDPG dehydrogenase, UDPG-DH, UDPG:NAD oxidoreductase, UDPGD, UDPGDH, UDPGDH-A, UDPGDH-B, UDPGlc dehydrogenase, UDPglucose dehydrogenase, UDPglucose:NAD+ oxidoreductase, Ugd, UGD1, UgdG, UGDH, uridine diphosphate D-glucose dehydrogenase, uridine diphosphate glucose dehydrogenase, uridine diphosphate glucose-6-dehydrogenase, uridine diphosphate-glucose dehydrogenase, uridine diphosphoglucose dehydrogenase, uridine-5'-diphosphoglucose dehydrogenase, uridyl phosphate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.22 UDP-glucose 6-dehydrogenase

Cloned

Cloned on EC 1.1.1.22 - UDP-glucose 6-dehydrogenase

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
-
expression in Agrobacterium tumefaciens; expression in Agrobacterium tumefaciens; expression in Agrobacterium tumefaciens; expression in Agrobacterium tumefaciens
expression in Escherichia coli
expression in Escherichia coli; expression in Escherichia coli
expression in Pichia pastoris
expression of isoforms Ugd2, Ugd3, Ugd4 in Escherichia coli
-
expression of mutant enzyme wild-type enzymes in Escherichia coli
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gene bceC, DNA and amino acid sequence determination and analysis, expression in Escherichia coli
-
gene Ugd(BCAL2946) cloned into the pGEM-T Easy vector, sequenced, and ligated into pET29a vector to transform Escherichia coli Top10 cells. Ugd(BCAL2946) expressed in Escherichia coli HMS 174(DE3); gene Ugd(BCAM0855) cloned into the pGEM-T Easy vector, sequenced, and ligated into pET29a vector to transform Escherichia coli Top10 cells. Ugd(BCAM0855) expressed in Escherichia coli HMS 174(DE3); gene Ugd(BCAM2034) cloned into the pGEM-T Easy vector, sequenced, and ligated into pET29a vector to transform Escherichia coli Top10 cells. Ugd(BCAM2034) expressed in Escherichia coli BL21 (DE3)
gene ugdG, expression of His6-tagged wild-type and selenomethionine-labeled UgdG in Escherichia coli BL21 and B843, respectively
genes szHasA (hyaluronan synthase gene) and szHasB (UDP-glucose-6-dehydrogenase gene) introduced into Lactococcus lactis strain NZ9000 under the control of nisA promoter and lacA promoter respectively, resulting in a dual-plasmid controlled expression system
-
hUGDH gene is cloned from a LNCaP cDNA library, from LNCaP C33 and C81 cells, expression of His6-tagged UGDH in Escherichia coli, expression of UGDH mutant D280N in HEK.293 cells
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overexpression as glutathione-S-transferase fusion protein in Escherichia coli
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overexpression in Escherichia coli JM109
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overexpression of the enzyme from Xenopus laevis in human smooth muscle cells increases the accumulation of hyaluronan
recombinant UGDH expressed in Escherichia coli
-