1.1.1.219: dihydroflavonol 4-reductase

This is an abbreviated version, for detailed information about dihydroflavonol 4-reductase, go to the full flat file.

Reaction

a (2R,3S,4S)-leucoanthocyanidin
+
NADP+
=
a (2R,3R)-dihydroflavonol
+
NADPH
+
H+

Synonyms

DFR, DFR1, DFR2, DFR3, DFR4a, DFR4b, DFR5, DHM reductase, DHQ reductase, dihydroflavanol 4-reductase, dihydroflavonol 4-reductase, dihydroflavonol reductase, dihydroflavonol-4-reductase, dihydrokaempferol 4-reductase, dihydromyricetin reductase, dihydroquercetin reductase, NADPH-dihydromyricetin reductase, PAS_chr3_0449, reductase, dihydromyricetin, reductase, dihydroquercetin, TRANSPARENT TESTA 3 protein

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.219 dihydroflavonol 4-reductase

Substrates Products

Substrates Products on EC 1.1.1.219 - dihydroflavonol 4-reductase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+)-2,3-dihydrokaempferol + NADPH
cis-3,4-leucopelargonidin + NADP+
show the reaction diagram
(+)-dihydrokaempferol + NADPH
cis-3,4-leucopelargonidin + NADP+
show the reaction diagram
(+)-dihydrokaempferol + NADPH + H+
cis-3,4-leucopelargonidin + NADP+
show the reaction diagram
-
-
-
?
(+)-dihydromyricetin + NADPH
cis-3,4-leucodelphinidin + NADP+
show the reaction diagram
(+)-dihydroquercetin + NADPH
cis-3,4-leucocyanidin + NADP+
show the reaction diagram
(+)-dihydroquercetin + NADPH + H+
cis-3,4-leucocyanidin + NADP+
show the reaction diagram
(+/-)-fustin + NADPH
?
show the reaction diagram
preference for (-)-isomer
-
-
?
(+/-)-taxifolin + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
(-)-fustin + NADPH
?
show the reaction diagram
stereospecific for (-)-isomer
-
-
?
(2E)-hex-2-enal + NADPH
(2E)-hex-2-en-1-ol + NADPH + H+
show the reaction diagram
(2R,3R)-(+)-dihydrokaempferol + NADPH
(2R,3S,4S)-cis-3,4-leucopelargonidin + NADP+
show the reaction diagram
(2R,3R)-dihydromyricetin + NADPH
(2R,3S,4R)-cis-3,4-leucodelphinidin + NADP+
show the reaction diagram
(2R,3R)-dihydroquercetin + NADPH
(2R,3S,4R)-leucocyanidin + NADP+
show the reaction diagram
(2S)-hexan-2-ol + NADP+
hexan-2-one + NADPH + H+
show the reaction diagram
(4S)-5,5,5-trifluoro-4-hydroxy-4-phenylpentan-2-one + NADPH + H+
(2S)-1,1,1-trifluoro-2-phenylpentane-2,4-diol + NADP+
show the reaction diagram
2,3-dihydromyricetin + NADPH
cis-3,4-leucodelphinidin + NADP+
show the reaction diagram
low activity
-
-
?
2,3-dihydroquercetin + NADPH
cis-3,4-leucocyanidin + NADP+
show the reaction diagram
i.e. (+)-taxifolin, stereospecific for (+)-isomer
-
-
?
2,3-dihydrorobinetin + NADPH
?
show the reaction diagram
-
-
-
?
2-methylpentanal + NADPH
2-methyl-pentan-1-ol + NADPH + H+
show the reaction diagram
7-hydroxyflavanone + NADPH + H+
2,4-cis-7-hydroxyflavan-4-ol + 2,4-trans-7-hydroxyflavan-4-ol + NADP+
show the reaction diagram
-
-
-
?
benzaldehyde + NADPH
benzyl alcohol + NADPH + H+
show the reaction diagram
-
-
-
?
butanal + NADPH
butan-1-ol + NADPH + H+
show the reaction diagram
176% of the activity with benzaldehyde
-
-
?
dihydroflavonol + NADPH
flavan-3,4-diol + NADP+
show the reaction diagram
-
-
-
-
?
dihydrokaempferol + NADPH
cis-3,4-leucopelargonidin + NADP+
show the reaction diagram
-
-
-
-
r
dihydrokaempferol + NADPH + H+
leucopelargonidin + NADP+
show the reaction diagram
dihydromyricetin + NADPH
cis-3,4-leucodelphinidin + NADP+
show the reaction diagram
-
-
-
-
?
dihydromyricetin + NADPH
leucodelphinidin + NADP+
show the reaction diagram
-
-
-
-
r
dihydromyricetin + NADPH + H+
leucodelphinidin + NADP+
show the reaction diagram
dihydroquercetin + NADPH
?
show the reaction diagram
-
assay at 25°C, pH 7.5
-
-
?
dihydroquercetin + NADPH
cis-3,4-leucocyanidin + NADP+
show the reaction diagram
dihydroquercetin + NADPH
leucocyanidin + NADP+
show the reaction diagram
-
-
-
-
r
dihydroquercetin + NADPH + H+
leucocyanidin + NADP+
show the reaction diagram
eriodictyol + NADPH + H+
luteoforol + NADP+
show the reaction diagram
heptan-2-one + NADPH + H+
(2S)-heptan-2-ol + NADP+
show the reaction diagram
-
99% conversion, 99% enantiomeric excess
-
r
hexan-2-one + NADPH + H+
(2S)-hexan-2-ol + NADP+
show the reaction diagram
-
99% conversion, 99% enantiomeric excess
-
r
hexanal + NADPH
hexan-1-ol + NADPH + H+
show the reaction diagram
74% of the activity with benzaldehyde
-
-
?
naringenin + NADPH + H+
apiferol + NADP+
show the reaction diagram
additional information
?
-