1.1.1.219: dihydroflavonol 4-reductase

This is an abbreviated version, for detailed information about dihydroflavonol 4-reductase, go to the full flat file.

Reaction

a (2R,3S,4S)-leucoanthocyanidin
+
NADP+
=
a (2R,3R)-dihydroflavonol
+
NADPH
+
H+

Synonyms

BrDFR1, BrDFR10, BrDFR11, BrDFR12, BrDFR2, BrDFR3, BrDFR4, BrDFR5, BrDFR6, BrDFR7, BrDFR8, BrDFR9, CsDFR, DcDFR, DFR, DFR1, DFR2, DFR3, DFR4a, DFR4b, DFR5, DgDFR, DHM reductase, DHQ reductase, dihydroflavanol 4-reductase, dihydroflavonol 4-reductase, dihydroflavonol reductase, dihydroflavonol-4-reductase, dihydrokaempferol 4-reductase, dihydromyricetin reductase, dihydroquercetin reductase, DnDFR, flavan-3-ol NADPH-dihydromycertin reductase, GbDFR1, GbDFR2, GbDFR3, IbDFR, McDFR, NADPH-dihydromyricetin reductase, PAS_chr3_0449, reductase, dihydromyricetin, reductase, dihydroquercetin, TaDFR, TaDFR-A, TaDFR-I, TRANSPARENT TESTA 3 protein

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.219 dihydroflavonol 4-reductase

Crystallization

Crystallization on EC 1.1.1.219 - dihydroflavonol 4-reductase

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Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
DFR-NADP+-flavonol (myricetin and quercetin) complexes, at room temperature, by hanging-drop vapour diffusion method. Complex DFR-NADP+-myricetin belongs to space group P21 (unit-cell parameters a = 47.23, b = 177.96, c = 92.60 A, beta = 104.8). Complex DFR-NADP+-quercetin belongs to space group P6122 (unit-cell parameters a = b = 174.94, c = 290.18 A)
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purified recombinant enzyme in complex with NADPH and dihydroquercetin, X-ray diffraction structure determination and analysis at 1.8 A resolution
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