1.1.1.214: 2-dehydropantolactone reductase (Si-specific)

This is an abbreviated version, for detailed information about 2-dehydropantolactone reductase (Si-specific), go to the full flat file.

Reaction

(R)-pantolactone
+
NADP+
=
2-dehydropantolactone
+
NADPH
+
H+

Synonyms

2-dehydropantoyl-lactone reductase (B-specific), 2-ketopantoyl lactone reductase, 2-oxopantoyl lactone reductase, conjugated polyketone reductase, conjugated polyketone reductase C2, CPR-C1, CPR-C2, ketopantoyl lactone reductase, NADPH-dependent conjugated polyketone reductase, NADPH-dependent ketopantoyl lactone reductase, nicotinamide adenine dinucleotide phosphate-dependent ketopantoyl lactone reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.214 2-dehydropantolactone reductase (Si-specific)

Reference

Reference on EC 1.1.1.214 - 2-dehydropantolactone reductase (Si-specific)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wilken, D.R.; King, H.L.; Dyar, R.E.
Ketopantoic acid and ketopantoyl lactone reductases. Stereospecificity of transfer of hydrogen from reduced nicotinamide adenine dinucleotide phosphate
J. Biol. Chem.
250
2311-2314
1975
Escherichia coli
Manually annotated by BRENDA team
Julliard, J.H.
Purification and characterization of oxopantoyl lactone reductase from higher plants: role in pantothenate synthesis
Bot. Acta
107
191-200
1994
Spinacia oleracea
-
Manually annotated by BRENDA team
Kataoka, M.; Delacruz-Hidalgo, A.R.G.; Akond, M.A.; Sakuradani, E.; Kita, K.; Shimizu, S.
Gene cloning and overexpression of two conjugated polyketone reductases, novel aldo-keto reductase family enzymes, of Candida parapsilosis. Investigation of hydroxamic acids as laccase-mediators for pulp bleaching
Appl. Microbiol. Biotechnol.
64
359-366
2004
Candida parapsilosis, Candida parapsilosis (Q76L36), Candida parapsilosis (Q76L37), Candida parapsilosis IFO 0708, Candida parapsilosis IFO 0708 (Q76L36), Candida parapsilosis IFO 0708 (Q76L37)
Manually annotated by BRENDA team
Qin, H.M.; Yamamura, A.; Miyakawa, T.; Kataoka, M.; Nagai, T.; Kitamura, N.; Urano, N.; Maruoka, S.; Ohtsuka, J.; Nagata, K.; Shimizu, S.; Tanokura, M.
Structure of conjugated polyketone reductase from Candida parapsilosis IFO 0708 reveals conformational changes for substrate recognition upon NADPH binding
Appl. Microbiol. Biotechnol.
98
243-249
2013
Candida parapsilosis (Q76L36), Candida parapsilosis IFO 0708, Candida parapsilosis IFO 0708 (Q76L36)
Manually annotated by BRENDA team
Qin, H.M.; Yamamura, A.; Miyakawa, T.; Kataoka, M.; Maruoka, S.; Ohtsuka, J.; Nagata, K.; Shimizu, S.; Tanokura, M.
Crystal structure of conjugated polyketone reductase (CPR-C1) from Candida parapsilosis IFO 0708 complexed with NADPH
Proteins
81
2059-2063
2013
Candida parapsilosis (Q76L37), Candida parapsilosis IFO 0708, Candida parapsilosis IFO 0708 (Q76L37)
Manually annotated by BRENDA team