1.1.1.213: 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)

This is an abbreviated version, for detailed information about 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific), go to the full flat file.

Reaction

a 3alpha-hydroxysteroid
+
NAD(P)+
=
a 3-oxosteroid
+
NAD(P)H
+
H+

Synonyms

17beta-hydroxysteroid dehydrogenase type 5, 3-alpha hydroxysteroid oxidoreductase, 3-alpha-HSO, 3alpha-HSD, 3alpha-HSD type 3, 3alpha-HSD/CR, 3alpha-HSD3, 3alpha-HSOR, 3alpha-hydroxysteroid dehydrogenase, 3alpha-hydroxysteroid dehydrogenase (B-specific), 3alpha-hydroxysteroid dehydrogenase type 2, 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase, 3alpha-hydroxysteroid oxido-reductase, 3alpha-hydroxysteroid oxidoreductase, 3alpha-hydroxysteroid:NAD(P) oxidoreductase, 3alphaHSD, A-specific 3alpha-hydroxysteroid dehydrogenase, AKR1C17, AKR1C2, AKR1C3, AKR1C4, AKR1C9, alpha-HSD/CR, B-specific 3alpha-hydroxysteroid dehydrogenase, bile acid-binding protein, DD2, dihydrodiol dehydrogenase, HSDH, More, NAD+-dependent 3alpha-HSD, NADP(H)-dependent 3alpha-HSD, type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 3 3-alpha-hydroxysteroid dehydrogenase, type 3 3alpha-HSD, type 3 3alpha-hydroxysteroid dehydrogenase, type 5 beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.213 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)

Turnover Number

Turnover Number on EC 1.1.1.213 - 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00063 - 0.85
(2Z)-2-(5-hydroxy-4,6-dimethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N,N-di(prop-2-en-1-yl)hydrazinecarbothioamide
0.115
(5beta,20R)-20-hydroxypregnan-3-one
Rattus norvegicus
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
0.008
3alpha-androstanediol
Homo sapiens
-
pH 7.0, 25°C, recombinant enzyme
1.13 - 1.25
3alpha-hydroxy-5alpha-androstan-17-one
0.148
4-oxo-2-nonenal
Homo sapiens
-
pH 7.4, 25°C
0.35
5alpha-androstan-17beta-ol-3-one
Mesocricetus auratus
-
-
0.267 - 0.567
5alpha-Androstan-3,17-dione
1.33
5alpha-androstan-3alpha,17beta-diol
Mesocricetus auratus
-
-
2.72
5alpha-Androstan-3alpha-ol-17-one
Mesocricetus auratus
-
-
0.42
5alpha-androstane-3,17-dione
Rattus norvegicus
-
pH 7.0, 25, reduction reaction
0.037 - 0.43
5alpha-dihydroprogesterone
0.033 - 1339
5alpha-dihydrotestosterone
0.767
5alpha-pregnan-21-ol-3,20-one
Mesocricetus auratus
-
-
0.233
5alpha-Pregnan-3alpha,21-diol-20-one
Mesocricetus auratus
-
-
0.45
5beta-androstan-3,17-dione
Mesocricetus auratus
-
-
1.2
5beta-Androstan-3alpha,17beta-diol
Mesocricetus auratus
-
-
1.33
5beta-Androstan-3alpha-ol-17-one
Mesocricetus auratus
-
-
0.047
5beta-androstane-3,17-dione
Rattus norvegicus
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
0.433
5beta-Dihydrocortisone
Mesocricetus auratus
-
-
0.417
5beta-pregnan-3,20-dione
Mesocricetus auratus
-
-
0.633
5beta-Pregnan-3alpha,21-diol-20-one
Mesocricetus auratus
-
-
0.767
5beta-Pregnan-3alpha-ol-20-one
Mesocricetus auratus
-
-
0.105
5beta-pregnane-3,20-dione
Rattus norvegicus
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
0.1
6-tert-butyl-2,3-epoxy-4-hydroxy-5-cyclohexen-1-one
Rattus norvegicus
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
0.183 - 3.93
9,10-phenanthrenequinone
0.0028 - 318
androsterone
0.022 - 0.733
Dehydrolithocholic acid
0.167
diacetyl
Rattus norvegicus
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
0.2
glycochenodeoxycholic acid
Mesocricetus auratus
-
-
0.233
glycolithocholic acid
Mesocricetus auratus
-
-
0.283
isatin
Rattus norvegicus
-
pH 7.4, 25°C, recombinant wild-type AKR1C17
0.217
lithocholic acid
Mesocricetus auratus
-
-
1.13 - 1.43
NAD+
0.283 - 0.367
NADH
additional information
additional information
-