1.1.1.211: long-chain-3-hydroxyacyl-CoA dehydrogenase

This is an abbreviated version, for detailed information about long-chain-3-hydroxyacyl-CoA dehydrogenase, go to the full flat file.

Reaction

a long-chain (S)-3-hydroxyacyl-CoA
+
NAD+
=
a long-chain 3-oxoacyl-CoA
+
NADH
+
H+

Synonyms

2-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-oxoacyl-CoA thiolase, 3-hydroxyacyl-CoA dehydrogenase, beta-hydroxyacyl-CoA dehydrogenase, enoyl-coenzyme A (CoA) hydratase/3-hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase trifunctional protein, LCHAD, LHCAD, long-chain 3-hydroxyacyl coenzyme A dehydrogenase, long-chain 3-hydroxyacyl-CoA dehydrogenase, long-chain L-3 hydroxyacyl-CoA dehydrogenase, mitochondrial trifunctional protein, More, MTP

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase

Systematic Name

Systematic Name on EC 1.1.1.211 - long-chain-3-hydroxyacyl-CoA dehydrogenase

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SYSTEMATIC NAME
IUBMB Comments
long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
This enzyme was purified from the mitochondrial inner membrane. The enzyme has a preference for long-chain substrates, and activity with a C16 substrate was 6- to 15-fold higher than with a C4 substrate (cf. EC 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase).