1.1.1.206: tropinone reductase I

This is an abbreviated version, for detailed information about tropinone reductase I, go to the full flat file.

Reaction

Tropine
+
NADP+
=
tropinone
+
NADPH
+
H+

Synonyms

dehydrogenase, tropine, More, TR-I, TRI, Tropine dehydrogenase, tropine-forming tropinone reductase, tropinone reductase, tropinone reductase I, tropinone reductase II

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.206 tropinone reductase I

Systematic Name

Systematic Name on EC 1.1.1.206 - tropinone reductase I

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SYSTEMATIC NAME
IUBMB Comments
tropine:NADP+ 3alpha-oxidoreductase
Also oxidizes other tropan-3alpha-ols, but not the corresponding beta-derivatives [1]. This enzyme along with EC 1.1.1.236, tropinone reductase II, represents a branch point in tropane alkaloid metabolism [4]. Tropine (the product of EC 1.1.1.206) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines [4]. Both enzymes are always found together in any given tropane-alkaloid-producing species, have a common substrate, tropinone, and are strictly stereospecific [3].