1.1.1.206: tropinone reductase I

This is an abbreviated version, for detailed information about tropinone reductase I, go to the full flat file.

Reaction

Tropine
+
NADP+
=
tropinone
+
NADPH
+
H+

Synonyms

BaTRI, dehydrogenase, tropine, DnTR1, DsTRI, More, TR-I, TR1, TRI, tropine biosynthetic tropinone reductase, Tropine dehydrogenase, tropine-forming reductase, tropine-forming tropinone reductase, tropinone reductase, tropinone reductase I, tropinone reductase II, tropinone reductase-I, WcTR-I, WsTR-I, WsTR-I protein

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.206 tropinone reductase I

Substrates Products

Substrates Products on EC 1.1.1.206 - tropinone reductase I

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-methylpyrrolidine + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
1-propyl-4-piperidone + NADPH + H+
1-propylpiperidin-4-ol + NADP+
show the reaction diagram
low activity
-
-
?
1-propyl-4-piperidone + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
2-pyrrolidone + NADPH + H+
2-hydroxypyrrolidine + NADP+
show the reaction diagram
very low activity
-
-
?
2-pyrrolidone + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
3-methyl-cyclohexanone + NADPH
3-methylcyclohexanol + NADP+
show the reaction diagram
-
85% of the reaction velocity with tropinone
-
-
?
3-methylcyclohexanone + NADP+
3-methylcyclohexanol + NADP+
show the reaction diagram
-
-
-
?
3-methylcyclohexanone + NADPH
3-methylcyclohexanol + NADP+
show the reaction diagram
3-methylcyclohexanone + NADPH + H+
3-methylcyclohexanol + NADP+
show the reaction diagram
-
-
-
?
3-methylcyclohexanone + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
3-quinuclidinone + NADPH + H+
1-azabicyclo[2.2.2]octan-3-ol + NADP+
show the reaction diagram
3-quinuclidinone + NADPH + H+
quinuclidin-3-ol + NADP+
show the reaction diagram
4-chlor-1-methylpiperidine + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
4-chloro-1-methylpiperidine + NADPH + H+
? + NADP+
show the reaction diagram
moderate activity
-
-
?
4-ethylcyclohexanone + NADPH
4-ethylcyclohexanol + NADP+
show the reaction diagram
4-ethylcyclohexanone + NADPH + H+
4-ethylcyclohexanol + NADP+
show the reaction diagram
4-methylcyclohexanone + NADPH
4-methylcyclohexanol + NADP+
show the reaction diagram
4-methylcyclohexanone + NADPH + H+
4-methylcyclohexanol + NADP+
show the reaction diagram
4-piperidone + NADPH + H+
4-hydroxypiperidin + NADP+
show the reaction diagram
very low activity
-
-
?
4-piperidone + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
4-tetrahydro-thiopyranone + NADPH
?
show the reaction diagram
-
83% of the reaction velocity with tropinone
-
-
?
7-hydroxytropinone + NADPH
7-hydroxytropan-3-ol + NADP+
show the reaction diagram
8-thiabicyclo(3,2,1)octane-3-one + NADPH
8-thiabicyclo(3,2,1)octane-3-ol + NADP+
show the reaction diagram
-
-
-
-
?
8-thiabicyclo[3.2.1]octan-3-one + NADPH
?
show the reaction diagram
exo-6-hydroxytropinone + NADPH + H+
? + NADP+
show the reaction diagram
N-(2-fluoroethyl)nortropinone + NADPH
N-(2-fluoroethyl)nortropan-3-ol + NADP+
show the reaction diagram
N-isopropylnortropinone + NADPH
N-isopropylnortropan-3-ol + NADP+
show the reaction diagram
N-methyl-4-pieridinone + NADPH
N-methyl-1-piperidinol + NADP+
show the reaction diagram
-
13% of the reaction velocity with tropinone
-
-
?
N-methyl-4-piperidinone + NADPH
N-methyl-1-piperidinol + NADP+
show the reaction diagram
-
180% of the reaction velocity with tropinone
-
-
?
N-methyl-4-piperidone + NADPH
1-methylpiperidin-4-ol + NADP+
show the reaction diagram
N-methyl-4-piperidone + NADPH + H+
1-methylpiperidin-4-ol + NADP+
show the reaction diagram
low activity
-
-
?
N-methyl-4-piperidone + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
N-methylpiperidine + NADPH + H+
? + NADP+
show the reaction diagram
N-propyl-4-piperidinone + NADPH
N-propylpiperidinol + NADP+
show the reaction diagram
-
78% of the reaction velocity with tropinone
-
-
?
N-propyl-4-piperidone + NADPH
1-propylpiperidin-4-ol + NADP+
show the reaction diagram
-
-
-
-
?
nortropine + NADP+
nortropinone + NADPH
show the reaction diagram
quinuclidinone + NADPH
?
show the reaction diagram
scopine + NADP+
scopinone + NADPH
show the reaction diagram
-
-
-
-
?
tetrahydro-4H-thiopyran-4-one + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
tetrahydro-4H-thiopyrane-4-one + NADPH + H+
? + NADP+
show the reaction diagram
moderate activity
-
-
?
tropine + NADP+
tropinone + NADPH
show the reaction diagram
tropine + NADP+
tropinone + NADPH + H+
show the reaction diagram
tropinone + NADPH + H+
pseudotropine + NADP+
show the reaction diagram
tropinone + NADPH + H+
tropine + NADP+
show the reaction diagram
tropinone + NADPH + H+
tropine + NADPH + H+
show the reaction diagram
the in vitro reaction kinetics predominantly favour the reaction direction of tropinone reduction
-
-
r
additional information
?
-