1.1.1.206: tropinone reductase I

This is an abbreviated version, for detailed information about tropinone reductase I, go to the full flat file.

Reaction

Tropine
+
NADP+
=
tropinone
+
NADPH
+
H+

Synonyms

dehydrogenase, tropine, More, TR-I, TRI, Tropine dehydrogenase, tropine-forming tropinone reductase, tropinone reductase, tropinone reductase I, tropinone reductase II

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.206 tropinone reductase I

Substrates Products

Substrates Products on EC 1.1.1.206 - tropinone reductase I

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-methylpyrrolidine + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
1-propyl-4-piperidone + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
2-pyrrolidone + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
3-methyl-cyclohexanone + NADPH
3-methylcyclohexanol + NADP+
show the reaction diagram
-
85% of the reaction velocity with tropinone
-
-
?
3-methylcyclohexanone + NADPH
3-methylcyclohexanol + NADP+
show the reaction diagram
3-methylcyclohexanone + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
3-quinuclidinone + NADPH + H+
quinuclidin-3-ol + NADP+
show the reaction diagram
4-chlor-1-methylpiperidine + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
4-ethylcyclohexanone + NADPH
4-ethylcyclohexanol + NADP+
show the reaction diagram
4-ethylcyclohexanone + NADPH + H+
4-ethylcyclohexanol + NADP+
show the reaction diagram
-
-
-
?
4-methylcyclohexanone + NADPH
4-methylcyclohexanol + NADP+
show the reaction diagram
4-methylcyclohexanone + NADPH + H+
4-methylcyclohexanol + NADP+
show the reaction diagram
-
-
-
?
4-piperidone + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
4-tetrahydro-thiopyranone + NADPH
?
show the reaction diagram
-
83% of the reaction velocity with tropinone
-
-
?
7-hydroxytropinone + NADPH
7-hydroxytropan-3-ol + NADP+
show the reaction diagram
8-thiabicyclo(3,2,1)octane-3-one + NADPH
8-thiabicyclo(3,2,1)octane-3-ol + NADP+
show the reaction diagram
-
-
-
-
?
8-thiabicyclo[3.2.1]octan-3-one + NADPH
?
show the reaction diagram
exo-6-hydroxytropinone + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
N-(2-fluoroethyl)nortropinone + NADPH
N-(2-fluoroethyl)nortropan-3-ol + NADP+
show the reaction diagram
N-isopropylnortropinone + NADPH
N-isopropylnortropan-3-ol + NADP+
show the reaction diagram
N-methyl-4-pieridinone + NADPH
N-methyl-1-piperidinol + NADP+
show the reaction diagram
-
13% of the reaction velocity with tropinone
-
-
?
N-methyl-4-piperidinone + NADPH
N-methyl-1-piperidinol + NADP+
show the reaction diagram
-
180% of the reaction velocity with tropinone
-
-
?
N-methyl-4-piperidone + NADPH
1-methylpiperidin-4-ol + NADP+
show the reaction diagram
N-methyl-4-piperidone + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
N-methylpiperidine + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
N-propyl-4-piperidinone + NADPH
N-propylpiperidinol + NADP+
show the reaction diagram
-
78% of the reaction velocity with tropinone
-
-
?
N-propyl-4-piperidone + NADPH
1-propylpiperidin-4-ol + NADP+
show the reaction diagram
-
-
-
-
?
nortropine + NADP+
nortropinone + NADPH
show the reaction diagram
quinuclidinone + NADPH
?
show the reaction diagram
scopine + NADP+
scopinone + NADPH
show the reaction diagram
-
-
-
-
?
tetrahydro-4H-thiopyran-4-one + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
?
tropine + NADP+
tropinone + NADPH
show the reaction diagram
tropine + NADP+
tropinone + NADPH + H+
show the reaction diagram
in vitro reaction kinetics show that the enzyme predominantly favours the reverse reaction
-
-
r
tropinone + NADPH + H+
pseudotropine + NADP+
show the reaction diagram
tropinone + NADPH + H+
tropine + NADP+
show the reaction diagram
additional information
?
-