1.1.1.206: tropinone reductase I

This is an abbreviated version, for detailed information about tropinone reductase I, go to the full flat file.

Reaction

Tropine
+
NADP+
=
tropinone
+
NADPH
+
H+

Synonyms

dehydrogenase, tropine, More, TR-I, TRI, Tropine dehydrogenase, tropine-forming tropinone reductase, tropinone reductase, tropinone reductase I, tropinone reductase II

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.206 tropinone reductase I

Inhibitors

Inhibitors on EC 1.1.1.206 - tropinone reductase I

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
8-thiabicyclo(3,2,1)octane-3-one
-
complete inhibition at 4 mM
Ca2+
-
0-15% inactivation at 1 mM
Cd2+
-
26-43% inactivation at 1 mM
Co2+
-
0-15% inactivation at 1 mM
Cu2+
-
99% inactivation at 1 mM
diethyl dicarbonate
-
complete inhibition at 0.1 mM
Fe2+
-
0-15% inactivation at 1 mM
Fe3+
-
0-15% inactivation at 1 mM
Hg2+
-
99% inactivation at 1 mM
K+
slight inhibitory effect at 5 mM
methyl jasmonate
inhibits expression of TRI in hairy roots
Mg2+
-
0-15% inactivation at 1 mM
Mn2+
-
0-15% inactivation at 1 mM
Na+
slight inhibitory effect at 5 mM
NH4+
slight inhibitory effect at 5 mM
Ni2+
-
0-15% inactivation at 1 mM
p-chloromercuribenzoate
-
strong inhibition at 0.1 and 1.0 mM
p-hydroxymercuribenzoate
-
14% inhibition at 0.01 mM, 56% inhibition at 0.1 mM, 100% inhibition at 1.0 mM
Zn2+
-
0-15% inactivation at 1 mM
additional information
-
not inhibited by EDTA and iodoacetamide
-