1.1.1.203: uronate dehydrogenase

This is an abbreviated version, for detailed information about uronate dehydrogenase, go to the full flat file.

Reaction

beta-D-galacturonate
+
NAD+
=
D-galactaro-1,5-lactone
+
NADH
+
H+

Synonyms

Atu3143, CsUDH, galacturonate acid reductase, GalUR, PfUDH, PmUDH, PnUDH, PSPTO_1053, PsUDH, Udh, uronate dehydrogenase, uronate:NAD-oxidoreductase, uronic acid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.203 uronate dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.203 - uronate dehydrogenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
D-galactaro-1,5-lactone
-
noncompetitve versus NAD+ and beta-D-glucuronate
Hg2+
-
complete inhibition at 1 mM
KCN
-
15% inhibition at 1 mM
N-ethylmaleimide
-
inhibition at 1 mM, reversal by an excess of L-cysteine
p-chloromercuribenzoic acid
-
60% inhibition at 1 mM, reversal by an excess of L-cysteine
additional information
-
inhibition mechanisms, overview
-