1.1.1.201: 7beta-hydroxysteroid dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about 7beta-hydroxysteroid dehydrogenase (NADP+), go to the full flat file.

Reaction

a 7beta-hydroxysteroid
+
NADP+
=
a 7-oxosteroid
+
NADPH
+
H+

Synonyms

7beta-HSD, 7beta-HSDH, 7beta-hydroxysteroid dehydrogenase, More, NADP-dependent 7beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.201 7beta-hydroxysteroid dehydrogenase (NADP+)

Substrates Products

Substrates Products on EC 1.1.1.201 - 7beta-hydroxysteroid dehydrogenase (NADP+)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3,7,12-triketo-5beta-cholanoic acid + NADPH
7beta-hydroxy-3,12-diketo-5beta-cholanoic acid + NADP+
show the reaction diagram
-
-
-
?
3,7,12-triketo-5beta-cholanoyl taurine + NADPH
7beta-hydroxy-3,12-diketo-5beta-cholanoyl taurine + NADP+
show the reaction diagram
-
-
-
?
3,7-diketo-5beta-cholanoic acid + NADPH
7beta-hydroxy-3-keto-5beta-cholanoic acid + NADP+
show the reaction diagram
3alpha,12alpha-dihydroxy-7-keto-5beta-cholanoic acid + NADPH
3alpha,7beta,12alpha-trihydroxy-5beta-cholanoic acid + NADP+
show the reaction diagram
3alpha,7beta,12alpha-trihydroxy-5beta-cholanoic acid + NADP+
3alpha,12alpha-dihydroxy-7-keto-5beta-cholanoic acid + NADPH
show the reaction diagram
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+
3alpha,7keto-dihydroxy--5beta-cholanoic acid + NADPH
show the reaction diagram
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+
3alpha,7keto-dihydroxy-5beta-cholanoic acid + NADPH
show the reaction diagram
3alpha,7beta-dihydroxy-5beta-cholanoyl glycine + NADP+
3alpha-hydroxy-7-keto-5beta-cholanoyl glycine + NADPH
show the reaction diagram
3alpha,7beta-dihydroxy-5beta-cholanoyl taurine + NADP+
3alpha-hydroxy-7-keto-5beta-cholanoyl taurine + NADPH
show the reaction diagram
3alpha-hydroxy-7,12-diketo-5beta-cholanoic acid + NADPH
3alpha,7beta-dihydroxy-12-keto-5beta-cholanoic acid + NADP+
show the reaction diagram
5-cholesten-3beta,7beta-diol + NADP+
5-cholesten-3beta-ol-7-one + NADPH
show the reaction diagram
-
i.e. 7beta-hydroxycholesterol
-
-
?
7,12-diketo-5beta-cholanoic acid + NADPH
7beta-hydroxy-12-keto-5beta-cholanoic acid + NADP+
show the reaction diagram
7-ketolithocholic acid + NADPH + H+
ursodeoxycholic acid + NADP+
show the reaction diagram
7beta-hydroxycholesterol + NADP+
7-oxocholesterol + NADPH
show the reaction diagram
-
-
-
-
?
corticosterone + NADP+
21-hydroxy-pregn-4-ene-3,11,20-trione + NADPH
show the reaction diagram
-
oxidation at C-11
-
-
?
cortisone + NADP+
? + NADPH
show the reaction diagram
-
oxidation at C-11
-
-
?
dehydrocholic acid + NADPH + H+
? + NADP+ + H+
show the reaction diagram
ursodeoxycholic acid + NADP+
7-ketolithocholic acid + NADPH + H+
show the reaction diagram
additional information
?
-
-
enzyme might also show 11beta-hydroxysteroid dehydrogenase activity, no activity with cholesterol, 7alpha-hydroxycholesterol, 25-hydroxycholesterol, pregnenolone, dehydroepiandrosterone, chenodoxycolic acid, and ursodeoxycholic acid
-
-
-