1.1.1.201: 7beta-hydroxysteroid dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about 7beta-hydroxysteroid dehydrogenase (NADP+), go to the full flat file.
Word Map on EC 1.1.1.201
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1.1.1.201
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synthesis
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ursodeoxycholic
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taurinates
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dehydrogenases
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nadph-dependent
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aerofaciens
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bile
- 1.1.1.201
- synthesis
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ursodeoxycholic
-
taurinates
- dehydrogenases
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nadph-dependent
- aerofaciens
- bile
Reaction
Synonyms
7beta-HSD, 7beta-HSDH, 7beta-hydroxysteroid dehydrogenase, More, NADP-dependent 7beta-hydroxysteroid dehydrogenase, RUMGNA_02585
ECTree
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General Information
General Information on EC 1.1.1.201 - 7beta-hydroxysteroid dehydrogenase (NADP+)
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physiological function
additional information
the 7beta-hydroxysteroid dehydrogenase from Ruminococcus gnavus strain N53 (ATCC 29149) contributes to ursodeoxycholic acid formation in the human colon
physiological function
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the 7beta-hydroxysteroid dehydrogenase from Ruminococcus gnavus strain N53 (ATCC 29149) contributes to ursodeoxycholic acid formation in the human colon
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crystal structure analysis reveals a loop gating active site accessibility, the bases of the specificity for NADP+, and the general architecture of the steroid binding site. Conserved residues Ser143 and Tyr156 of 7beta-HSDH are homologous with and structurally superimpose to Ser146 and Tyr159 of 7alpha-HSDH
additional information
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crystal structure analysis reveals a loop gating active site accessibility, the bases of the specificity for NADP+, and the general architecture of the steroid binding site. Conserved residues Ser143 and Tyr156 of 7beta-HSDH are homologous with and structurally superimpose to Ser146 and Tyr159 of 7alpha-HSDH
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