1.1.1.197: 15-hydroxyprostaglandin dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about 15-hydroxyprostaglandin dehydrogenase (NADP+), go to the full flat file.

Reaction

(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate
+
NADP+
=
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate
+
NADPH
+
H+

Synonyms

9-ketoprostaglandin reductase, carbonyl reductase, NADP-dependent 15-hydroxyprostaglandin dehydrogenase, NADP-linked 15-hydroxyprostglandin dehydrogenase, NADP-specific 15-hydroxyprostaglandin dehydrogenase, prostaglandin 9-ketoreductase, prostaglandin E 9-ketoreductase, type II 15-hydroxyprostaglandin dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+)

Substrates Products

Substrates Products on EC 1.1.1.197 - 15-hydroxyprostaglandin dehydrogenase (NADP+)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-methyl-3-glutathionyl-1,4-benzoquinone + NADPH
? + NADP+
show the reaction diagram
-
toluquinone thioether
-
-
?
2-methyl-3-glutathionyl-1,4-naphthoquinone + NADPH
? + NADP+
show the reaction diagram
-
menadione thioether
-
-
?
4,5-benzo[a]pyrenequinone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
5,6-chrysenequinone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
7,8-benzo[a]pyrenequinone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
9,10-phenanthrenequinone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
acid form of latanoprost + NADP+
? + NADPH
show the reaction diagram
-
-
-
?
glutathione-9-hydroxy-prostaglandin A1 thioether + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
?
glutathione-prostaglandin A1 thioether + NADP+
? + NADPH
show the reaction diagram
-
PGA1-SG, excellent substrate for the placental enzyme
-
-
?
latanoprost + NADP+
? + NADPH
show the reaction diagram
-
-
-
?
menadione + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
prostaglandin A1 + NADP+
15-oxoprostaglandin A1 + NADPH + H+
show the reaction diagram
-
-
-
-
?
prostaglandin B1 + NADP+
15-oxoprostaglandin B1 + NADPH + H+
show the reaction diagram
-
-
-
-
?
prostaglandin E + NADP+
? + NADPH
show the reaction diagram
prostaglandin E1 + NADP+
15-keto-prostaglandin E1 + NADPH + H+
show the reaction diagram
-
-
-
-
?
prostaglandin E2 + NADP+
15-oxoprostaglandin E2 + NADPH + H+
show the reaction diagram
-
-
-
-
?
prostaglandin E2 + NADP+
prostaglandin F2alpha + NADPH
show the reaction diagram
prostaglandin F + NADP+
? + NADPH
show the reaction diagram
prostaglandin F2alpha + NADP+
prostaglandin E1 + NADPH
show the reaction diagram
prostaglandin I2 + NADP+
? + NADPH
show the reaction diagram
-
poor substrate for the enzyme
-
-
?
thromboxane B2 + NADP+
? + NADPH
show the reaction diagram
-
slowly oxidized
-
-
?
toluquinone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
the trans-dihydrodiols trans-dihydroxy-4,5-dihydrobenzo[alpha]pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo[alpha]pyrene, trans-3,4-dihydroxy-3,4-dihydrobenz[alpha]anthracene and its 7-methyl, 12-methyl, and 7,12-dimethyl derivatives are not substrates for the enzyme
-
-
-