1.1.1.197: 15-hydroxyprostaglandin dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about 15-hydroxyprostaglandin dehydrogenase (NADP+), go to the full flat file.

Reaction

(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate
+
NADP+
=
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate
+
NADPH
+
H+

Synonyms

9-ketoprostaglandin reductase, carbonyl reductase, NADP-dependent 15-hydroxyprostaglandin dehydrogenase, NADP-linked 15-hydroxyprostglandin dehydrogenase, NADP-specific 15-hydroxyprostaglandin dehydrogenase, prostaglandin 9-ketoreductase, prostaglandin E 9-ketoreductase, type II 15-hydroxyprostaglandin dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+)

Specific Activity

Specific Activity on EC 1.1.1.197 - 15-hydroxyprostaglandin dehydrogenase (NADP+)

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0012
substrate latanoprost, pH 7.0, 25C
0.0022
substrate acid form of latanoprost, pH 7.0, 25C
0.0061
substrate prostaglandin F2alpha, cosubstrate NAD+, pH 7.0, 25C
0.0098
substrate prostaglandin E2, cosubstrate NADP+, pH 7.0, 25C
0.0243
substrate prostaglandin F2alpha, cosubstrate NADP+, pH 7.0, 25C
0.09
-
-
6.8
-
form I, pI 5.8
7.5
-
form II, pI 4.8