1.1.1.197: 15-hydroxyprostaglandin dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about 15-hydroxyprostaglandin dehydrogenase (NADP+), go to the full flat file.

Reaction

(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate
+
NADP+
=
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate
+
NADPH
+
H+

Synonyms

9-ketoprostaglandin reductase, carbonyl reductase, NADP-dependent 15-hydroxyprostaglandin dehydrogenase, NADP-linked 15-hydroxyprostglandin dehydrogenase, NADP-specific 15-hydroxyprostaglandin dehydrogenase, prostaglandin 9-ketoreductase, prostaglandin E 9-ketoreductase, type II 15-hydroxyprostaglandin dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+)

Reference

Reference on EC 1.1.1.197 - 15-hydroxyprostaglandin dehydrogenase (NADP+)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Westbrook, C.; Lin, Y.M.; Jarabak, J.
NADP-linked 15-hydroxyprostaglandin dehydrogenase from human placenta: partial purification and characterization of the enzyme and identification of an inhibitor in placental tissue
Biochem. Biophys. Res. Commun.
76
943-949
1977
Homo sapiens
Manually annotated by BRENDA team
Wong, P.Y.K.; McGiff, J.C.
Detection of 15-hydroxyprostaglandin dehydrogenase in bovine mesenteric blood vessels
Biochim. Biophys. Acta
500
436-439
1977
Bos taurus
Manually annotated by BRENDA team
Jarabak, J.; Fried, J.
Comparison of substrate specificities of the human placental NAD-and NADP-linked 15-hydroxyprostaglandin dehydrogenases
Prostaglandins
18
241-246
1979
Homo sapiens
Manually annotated by BRENDA team
Levasseur, S.; Friedman, Y.; Burke, G.
Prostaglandin metabolism in the rat adrenal cortex: Characterization of prostaglandin-9-ketoreductase and 15-hydroxyprostaglandin dehydrogenase
Biochem. Biophys. Res. Commun.
95
236-242
1980
Homo sapiens, Platyrrhini, Rattus norvegicus
Manually annotated by BRENDA team
Chang, D.B.G; Sun, M.; Tai, H.H.
Prostaglandin-9-ketoreductase and type II 15-hydroxyprostaglandin dehydrogenase from swine kidney are alternate activities of a single enzyme protein
Biochem. Biophys. Res. Commun.
99
745-751
1981
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Tai, H.H.; Chang, D.B.G.
Purification of NADP+/NADPH-dependent 15-hydroxyprostaglandin dehydrogenase and prostaglandin 9-ketoreductase from porcine kidney
Methods Enzymol.
86
142-147
1982
Sus scrofa
Manually annotated by BRENDA team
Chung, H.; Fried, J.; Williams-Ashman, E.; Jarabak, J.
Glutathione mixed disulfide inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase
Prostaglandins
33
383-390
1987
Homo sapiens
Manually annotated by BRENDA team
Chung, H.; Harvey, R.G.; Armstrong, R.N.; Jarabak, J.
Polycyclic aromatic hydrocarbon quinones and glutathione thioethers as substrates and inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase
J. Biol. Chem.
262
12448-12451
1987
Homo sapiens
Manually annotated by BRENDA team
Wermuth, B.
NADP-dependent 15-hydroxyprostaglandin dehydrogenase is homologous to NAD-dependent 15-hydroxyprostaglandin dehydrogenase and other short-chain alcohol dehydrogenases
Prostaglandins
44
5-9
1992
Homo sapiens
Manually annotated by BRENDA team
Krook, M.; Ghosh, D.; Duax, W.; Jörnvall, H.
Three-dimensional model of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase and relationships to the NADP(+)-dependent enzyme (carbonyl reductase)
FEBS Lett.
322
139-142
1993
Homo sapiens
Manually annotated by BRENDA team
Fujimori, K.; Okada, T.; Urade, Y.
Expression of NADP(+)-Dependent 15-Hydroxyprostaglandin Dehydrogenase mRNA in Monkey Ocular Tissues and Characterization of Its Recombinant Enzyme
J. Biochem.
131
383-389
2002
Macaca fascicularis (Q8MI29)
Manually annotated by BRENDA team
Krook, M.; Ghosh, D.; Stromberg, R.; Carlquist, M.; Jornvall, H.
Carboxyethyllysine in a protein: Native carbonyl reductase/NADP+-dependent prostaglandin dehydrogenase
Proc. Natl. Acad. Sci. USA
90
502-506
1993
Homo sapiens
Manually annotated by BRENDA team