1.1.1.197: 15-hydroxyprostaglandin dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about 15-hydroxyprostaglandin dehydrogenase (NADP+), go to the full flat file.

Reaction

(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate
+
NADP+
=
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate
+
NADPH
+
H+

Synonyms

9-ketoprostaglandin reductase, carbonyl reductase, NADP-dependent 15-hydroxyprostaglandin dehydrogenase, NADP-linked 15-hydroxyprostglandin dehydrogenase, NADP-specific 15-hydroxyprostaglandin dehydrogenase, prostaglandin 9-ketoreductase, prostaglandin E 9-ketoreductase, type II 15-hydroxyprostaglandin dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+)

KM Value

KM Value on EC 1.1.1.197 - 15-hydroxyprostaglandin dehydrogenase (NADP+)

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0024
2-methyl-3-glutathionyl-1,4-benzoquinone
-
-
0.0034
2-methyl-3-glutathionyl-1,4-naphthoquinone
-
-
0.00018
4,5-benzo[a]pyrenequinone
-
-
0.00051
5,6-chrysenequinone
-
-
0.00087
7,8-benzo[a]pyrenequinone
-
-
-
0.00036
9,10-phenanthrenequinone
-
-
0.00033
glutathione-prostaglandin A1 thioether
-
-
-
0.0076
menadione
-
-
0.09
prostaglandin A1
-
-
0.157
prostaglandin E1
-
-
0.03
toluquinone
-
-