1.1.1.197: 15-hydroxyprostaglandin dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about 15-hydroxyprostaglandin dehydrogenase (NADP+), go to the full flat file.

Reaction

(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate
+
NADP+
=
(13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate
+
NADPH
+
H+

Synonyms

9-ketoprostaglandin reductase, carbonyl reductase, NADP-dependent 15-hydroxyprostaglandin dehydrogenase, NADP-linked 15-hydroxyprostglandin dehydrogenase, NADP-specific 15-hydroxyprostaglandin dehydrogenase, prostaglandin 9-ketoreductase, prostaglandin E 9-ketoreductase, type II 15-hydroxyprostaglandin dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+)

Inhibitors

Inhibitors on EC 1.1.1.197 - 15-hydroxyprostaglandin dehydrogenase (NADP+)

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-glutathionyl-2-hydroxy-3(allyloxy)propane
-
competitive inhibition of prostaglandin B1 oxidation
beta-mercaptoacetate
-
-
beta-mercaptolactate
-
-
beta-Mercaptopyruvate
-
-
glutathione-9-hydroxy-prostaglandin A1 thioether
-
inhibition of polycyclic aromatic hydrocarbon quinone reduction
-
GSSG
-
-