1.1.1.196: 15-hydroxyprostaglandin-D dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about 15-hydroxyprostaglandin-D dehydrogenase (NADP+), go to the full flat file.

Reaction

(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
+
NADP+
=
(5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
+
NADPH
+
H+

Synonyms

15-hydroxy PGD2 dehydrogenase, 15-hydroxy prostaglandin dehydrogenase (NADP+), dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate), dehydrogenase, prostaglandin D2, NADP+-dependent 15-hydroxyprostaglandin dehydrogenase, NADP+-linked 15-hydroxyprostaglandin dehydrogenase, NADP+-linkedprostaglandin D2 dehydrogenase, NADP+-specific 15-hydroxyprostaglandindehydrogenase, NADP-PGD2 dehydrogenase, prostaglandin D2 dehydrogenase, prostaglandin-D 15-dehydrogenase (NADP+)

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)

Substrates Products

Substrates Products on EC 1.1.1.196 - 15-hydroxyprostaglandin-D dehydrogenase (NADP+)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
15-keto-DELTA13-prostaglandin + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
?
prostaglandin A2 + NADP+
15-ketoprostaglandin A2 + NADPH + H+
show the reaction diagram
-
poor substrate for this enzyme, rates of reaction being less than 10% of that with prostaglandin D2
-
-
?
prostaglandin B2 + NADP+
15-ketoprostaglandin B2 + NADPH + H+
show the reaction diagram
-
poor substrate for this enzyme, rates of reaction being less than 10% of that with prostaglandin D2
-
-
?
prostaglandin D1 + NADP+
15-ketoprostaglandin D1 + NADPH + H+
show the reaction diagram
-
-
-
-
?
prostaglandin D2 + NADP+
15-ketoprostaglandin D2 + NADPH + H+
show the reaction diagram
prostaglandin D3 + NADP+
15-ketoprostaglandin D3 + NADPH + H+
show the reaction diagram
-
poor substrate for this enzyme, rates of reaction being less than 10% of that with prostaglandin D2
-
-
?
prostaglandin E2 + NADP+
15-ketoprostaglandin E2 + NADPH + H+
show the reaction diagram
prostaglandin F2alpha + NADP+
15-ketoprostaglandin F2alpha + NADPH + H+
show the reaction diagram
prostaglandin I2 + NADP+
15-ketoprostaglandin I2 + NADPH + H+
show the reaction diagram
-
-
-
-
?