1.1.1.196: 15-hydroxyprostaglandin-D dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about 15-hydroxyprostaglandin-D dehydrogenase (NADP+), go to the full flat file.

Reaction

(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
+
NADP+
=
(5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
+
NADPH
+
H+

Synonyms

15-hydroxy PGD2 dehydrogenase, 15-hydroxy prostaglandin dehydrogenase (NADP+), dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate), dehydrogenase, prostaglandin D2, NADP+-dependent 15-hydroxyprostaglandin dehydrogenase, NADP+-linked 15-hydroxyprostaglandin dehydrogenase, NADP+-linkedprostaglandin D2 dehydrogenase, NADP+-specific 15-hydroxyprostaglandindehydrogenase, NADP-PGD2 dehydrogenase, prostaglandin D2 dehydrogenase, prostaglandin-D 15-dehydrogenase (NADP+)

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)

Reference

Reference on EC 1.1.1.196 - 15-hydroxyprostaglandin-D dehydrogenase (NADP+)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Watanabe, K.; Shimizu, T.; Iguchi, S.; Wakatsuka, H.; Hayashi, M.; Hayaishi, O.
An NADP-linked prostaglandin D dehydrogenase in swine brain
J. Biol. Chem.
255
1779-1782
1980
Sus scrofa
Manually annotated by BRENDA team
Shimizu, T.; Watanabe, K.; Tokumoto, H.; Hayaishi, O.
Isolation of NADP+-dependent PGD2-specific 15-hydroxyprostaglandin dehydrogenase from swine brain
Methods Enzymol.
86
147-152
1982
Sus scrofa
Manually annotated by BRENDA team
Tokumoto, H.; Watanabe, K.; Fukushima, D.; Shimizu, T.; Hayaishi, O.
An NADP-linked 15-hydroxyprostaglandin dehydrogenase specific for prostaglandin D2 from swine brain
J. Biol. Chem.
257
13576-13580
1982
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team