1.1.1.196: 15-hydroxyprostaglandin-D dehydrogenase (NADP+)

This is an abbreviated version, for detailed information about 15-hydroxyprostaglandin-D dehydrogenase (NADP+), go to the full flat file.

Reaction

(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
+
NADP+
=
(5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
+
NADPH
+
H+

Synonyms

15-hydroxy PGD2 dehydrogenase, 15-hydroxy prostaglandin dehydrogenase (NADP+), dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate), dehydrogenase, prostaglandin D2, NADP+-dependent 15-hydroxyprostaglandin dehydrogenase, NADP+-linked 15-hydroxyprostaglandin dehydrogenase, NADP+-linkedprostaglandin D2 dehydrogenase, NADP+-specific 15-hydroxyprostaglandindehydrogenase, NADP-PGD2 dehydrogenase, prostaglandin D2 dehydrogenase, prostaglandin-D 15-dehydrogenase (NADP+)

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)

General Stability

General Stability on EC 1.1.1.196 - 15-hydroxyprostaglandin-D dehydrogenase (NADP+)

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
enzyme is quite unstable at the low protein concentrations less than 10 mg/ml, sulfhydryl reagents like dithiothreitol, 2-mercaptoethanol and reduced glutathione protect the enzyme from inactivation
-
unstable
-