1.1.1.191: indole-3-acetaldehyde reductase (NADPH)

This is an abbreviated version, for detailed information about indole-3-acetaldehyde reductase (NADPH), go to the full flat file.

Reaction

(indol-3-yl)ethanol
+
NADP+
=
(indol-3-yl)acetaldehyde
+
NADPH
+
H+

Synonyms

indoleacetaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.191 indole-3-acetaldehyde reductase (NADPH)

Inhibitors

Inhibitors on EC 1.1.1.191 - indole-3-acetaldehyde reductase (NADPH)

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Cd2+
-
complete inhibition at 2 mM
dihydroxyacetonephosphate
-
non-competitive inhibition, Ki: 0.35 mM
EDTA
-
40% inhibition at 1 mM
indole-3-acetic acid
-
inhibitory above 0.05 mM
Indole-3-aldehyde
-
slight inhibition at 0.2 mM
indole-3-glycolate
-
62% inhibition at 0.2 mM
iodoacetate
KCN
-
73% inhibition at 1 mM
KI
-
23% inhibition at 1 mM
Mn2+
-
46% inhibition at 1 mM
N-ethylmaleimide
-
46% inhibition at 1 mM
NADP+
-
non-competitive inhibition, half-maximal inhibition at 0.2 mM
NADPH
NaF
-
35% inhibition at 1 mM
NaN3
-
slight inhibition at 1 mM
p-chloromercuribenzoate
-
17% inhibition at 0.1 mM
p-Chloromercuriphenylsulfonic acid
-
46% inhibition at 0.1 mM
p-hydroxymercuribenzoate
-
40% inhibition at 0.1 mM
tryptophan
-
inhibition at low concentrations
Zn2+
-
36% inhibition at 1 mM