1.1.1.188: prostaglandin-F synthase

This is an abbreviated version, for detailed information about prostaglandin-F synthase, go to the full flat file.

Reaction

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate
+
NADP+
=
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
+
NADPH
+
H+

Synonyms

20alpha-HSD/PGFS, 20alpha-hydroxysteroid dehydrogenase/prostaglandin F-synthase, AKR1B1, AKR1B3, AKR1B7, AKR1C3, aldo-keto reductase, aldo-keto reductase 1C3, ALDR1, ALR2, DD1, dihydrodiol dehydrogenase 1, m-PGFS, More, NADPH-dependent prostaglandin D2 11-keto reductase, PG endoperoxide reductase, PGD 11-ketoreductase, PGD2 11-ketoreductase, PGD2 11-ketoreductase activity, PGF synthase, PGF synthase I, PGF synthase II, PGF2alpha synthase, PGF2alpha-synthetic activity, PGFS, PGFS I, PGFS-I, PGFS-II, PGFSI, PGFSII, PGH 9-,11-endoperoxide reductase, PGH2 9,11-endoperoxidase, PGH2 9,11-endoperoxide reductase, PGH2 9-,11-endoperoxide reductase, prostaglandin 11-keto reductase, prostaglandin 11-ketoreductase, prostaglandin D2 11-ketoreductase, prostaglandin D2-ketoreductase, prostaglandin F synthase, prostaglandin F synthase I, prostaglandin F synthase II, prostaglandin F synthetase, prostaglandin F2alpha synthase, prostaglandin F2alpha-synthase, prostaglandin-D2 11-reductase, prostaglandin-F2alpha synthase, prostamide/PGF synthase, prostamide/prostaglandin F synthase, reductase, 15-hydroxy-11-oxoprostaglandin, synthetase, prostaglandin F2alpha, type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase, vas deferens protein

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.188 prostaglandin-F synthase

Substrates Products

Substrates Products on EC 1.1.1.188 - prostaglandin-F synthase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
show the reaction diagram
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH
(5Z,13E)-(15S)-9alpha,11beta,15-trihydroxyprosta-5,13-dienoate + NADP+
show the reaction diagram
4-nitroacetophenone + NADPH
?
show the reaction diagram
-
high activity
-
-
?
4-nitrobenzaldehyde + NADPH
4-nitrobenzalcohol + NADP+
show the reaction diagram
-
high activity
-
-
?
4-nitrobenzaldehyde + NADPH
4-nitrobenzyl alcohol + NADP+
show the reaction diagram
4-nitrobenzaldehyde + NADPH + H+
(4-nitrophenyl)methanol + NADP+
show the reaction diagram
5beta-androstane-3,17-dione + NADPH
5beta-androstan-3alpha-ol-17-one + NADP+
show the reaction diagram
-
-
-
-
r
5beta-dihydrotestosterone + NADPH
?
show the reaction diagram
-
-
-
-
?
9,10-phenanthrenequinone + NADPH
?
show the reaction diagram
9,10-phenanthrenequinone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
9,10-phenanthrenequinone + NADPH + H+
?
show the reaction diagram
-
-
-
-
?
androst-4-ene-3,17-dione + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
cyclohexanone + NADPH
cyclohexanol + NADP+
show the reaction diagram
D-xylose + NADPH
?
show the reaction diagram
-
-
-
-
?
daunorubicin + NADPH
?
show the reaction diagram
-
high activity
-
-
?
DL-glyceraldehyde + NADPH
DL-glycerol + NADP+
show the reaction diagram
-
-
-
-
?
DL-glyceraldehyde + NADPH
glyceral + NADP+
show the reaction diagram
-
-
-
-
?
duroquinone + NADPH
?
show the reaction diagram
-
-
-
-
?
hydrindantin + NADPH
?
show the reaction diagram
menadione + NADPH
?
show the reaction diagram
n-butyraldehyde + NADPH
n-butanol + NADP+
show the reaction diagram
-
-
-
-
?
p-nitroacetophenone + NADPH
?
show the reaction diagram
-
-
-
-
?
phenylglyoxal + NADPH
?
show the reaction diagram
prostaglandin A2 + NADPH
?
show the reaction diagram
-
-
-
-
?
prostaglandin D1 + NADPH
?
show the reaction diagram
-
-
-
-
?
prostaglandin D2 + NADPH
9alpha,11alpha-prostaglandin F2alpha + NADP+
show the reaction diagram
prostaglandin D2 + NADPH
9alpha,11beta-prostaglandin F2 + NADP+
show the reaction diagram
prostaglandin D2 + NADPH
9alpha,11beta-prostaglandin F2alpha + NADP+
show the reaction diagram
-
-
-
-
r
prostaglandin D2 + NADPH
9alpha,11beta-prostaglandin F2alphabeta + NADP+
show the reaction diagram
-
-
-
-
?
prostaglandin D2 + NADPH
prostaglandin F2alpha + NADP+
show the reaction diagram
-
-
-
?
prostaglandin D2 + NADPH + H+
9-alpha,11-beta-prostaglandin F2 + NADP+
show the reaction diagram
-
-
-
-
?
prostaglandin D2 + NADPH + H+
9alpha,11beta-prostaglandin F2 + NADP+
show the reaction diagram
prostaglandin D2 + NADPH + H+
prostaglandin 9alpha,11beta-F2 + NADP+
show the reaction diagram
prostaglandin D2 ethanolamide + NADPH
prostaglandin 9alpha,11beta-F2 ethanolamide + NADP+
show the reaction diagram
i.e. prostamide D2
i.e. 91lpha,11beta-prostamide F2
-
?
prostaglandin D3 + NADPH
?
show the reaction diagram
-
-
-
-
?
prostaglandin H2 + NADPH
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
show the reaction diagram
prostaglandin H2 + NADPH
9alpha,11alpha-prostaglandin F2alpha + NADP+
show the reaction diagram
prostaglandin H2 + NADPH
prostaglandin 9alpha,11beta-F2 + NADP+
show the reaction diagram
-
-
-
?
prostaglandin H2 + NADPH
prostaglandin D2 + NADP+
show the reaction diagram
prostaglandin H2 + NADPH
prostaglandin F2alpha + NADP+
show the reaction diagram
prostaglandin H2 + NADPH + H+
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
show the reaction diagram
aldo-keto reductase has prostaglandin F2alpha synthase activity. AKR1B1 is a more efficient prostaglandin F2alpha synthase than AKR1C3
-
-
?
prostaglandin H2 + NADPH + H+
9alpha,11beta-prostaglandin F2 + NADP+
show the reaction diagram
prostaglandin H2 + NADPH + H+
prostaglandin F2alpha + NADP+
show the reaction diagram
prostaglandin I2 + NADPH
?
show the reaction diagram
-
-
-
-
?
prostamide D2 + NADPH + H+
9alpha,11beta-prostamide F2 + NADP+
show the reaction diagram
-
-
-
?
prostamide H2 + NADPH + H+
prostamide F2alpha + NADP+
show the reaction diagram
-
about 70% of prostamide H2 is converted to prostamide F2alpha after 2 min at 37°C
-
-
?
retinal + NADPH
retinol + NADP+
show the reaction diagram
-
-
-
-
?
testosterone + NADPH
?
show the reaction diagram
-
-
-
-
?
ubiquinone-10 + NADPH
?
show the reaction diagram
-
-
-
-
?
additional information
?
-