1.1.1.188: prostaglandin-F synthase

This is an abbreviated version, for detailed information about prostaglandin-F synthase, go to the full flat file.

Reaction

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate
+
NADP+
=
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
+
NADPH
+
H+

Synonyms

17beta-hydroxysteroid dehydrogenase type 5, 17betaHSD5, 20alpha-HSD/PGFS, 20alpha-hydroxysteroid dehydrogenase/prostaglandin F-synthase, 9,11-endoperoxidase reductase, AKR1B1, AKR1B3, AKR1B7, AKR1C3, aldo-keto reductase, aldo-keto reductase 1C3, aldo-ketoreductase 1B1, ALDR1, ALR2, DD1, dihydrodiol dehydrogenase 1, LemaA.00019.a.B1, m-PGFS, More, NADPH-dependent prostaglandin D2 11-keto reductase, P100/11E, PG endoperoxide reductase, PGD 11-ketoreductase, PGD2 11-ketoreductase, PGD2 11-ketoreductase activity, PGF, PGF synthase, PGF synthase I, PGF synthase II, PGF2alpha synthase, PGF2alpha-synthase, PGF2alpha-synthetic activity, PGFS, PGFS I, PGFS-I, PGFS-II, PGFSI, PGFSII, PGH 9-,11-endoperoxide reductase, PGH2 9,11-endoperoxidase, PGH2 9,11-endoperoxide reductase, PGH2 9-,11-endoperoxide reductase, prostaglandin 11-keto reductase, prostaglandin 11-ketoreductase, prostaglandin D2 11-ketoreductase, prostaglandin D2-ketoreductase, prostaglandin F synthase, prostaglandin F synthase I, prostaglandin F synthase II, prostaglandin F synthetase, prostaglandin F2alpha synthase, prostaglandin F2alpha-synthase, prostaglandin-D2 11-reductase, prostaglandin-F2alpha synthase, prostamide/PGF synthase, prostamide/prostaglandin F synthase, reductase, 15-hydroxy-11-oxoprostaglandin, synthetase, prostaglandin F2alpha, Tc00.1047053511287.49, TrcrA.00019.a.B1, type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase, vas deferens protein

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.188 prostaglandin-F synthase

Specific Activity

Specific Activity on EC 1.1.1.188 - prostaglandin-F synthase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0015
-
prostaglandin D2 as substrate
0.003
-
prostaglandin H2 as substrate; purified liver-type isozyme, substrate prostaglandin H2
0.008
-
purified liver-type isozyme, substrate prostaglandin I2
0.034
-
-
0.041
purified recombinant enzyme, pH 7.0, 25C, in presence of 0.05 mM 9,10-phenanthrenequinone
0.046
-
prostaglandin D1 as substrate; purified liver-type isozyme, substrate prostaglandin D1
0.062
PGF synthase activity of the purified enzyme
0.065
-
xylose as substrate
0.078
-
purified recombinant enzyme, pH 7.0, 25C, in presence of 0.05 mM 9,10-phenanthrenequinone
0.089
-
prostaglandin D3 as substrate; purified liver-type isozyme, substrate prostaglandin D3
0.095
-
prostaglandin D2 as substrate; purified liver-type isozyme, substrate prostaglandin D2
0.115
-
4-nitrobenzaldehyde reductase activity
0.13
-
5beta-dihydrotestosterone as substrate
0.15
-
prostaglandin F2alpha as product
0.159
-
cyclohexanone as substrate
0.167
-
menadione and hydrindantin as substrate
0.174
-
4-nitroacetophenone as substrate
0.2
-
about, purified recombinant enzyme, pH 7.0, 25C
0.206
-
DL-glyceraldehyde as substrate
0.207
-
phenylglyoxal as substrate
0.31
-
4-nitrobenzaldehyde as substrate; purified liver-type isozyme, substrate 4-nitrobenzaldehyde
0.339
-
9,10-phenanthrenequinone as substrate; purified liver-type isozyme, substrate 9,10-phenanthrenequinone
0.41
about, purified recombinant enzyme, pH 7.0, 25C
0.69
-
PGF synthase activity of the purified enzyme
2.4
-
pH 5.5, 37C
3.6
-
pH 5.0, 37C
additional information