1.1.1.188: prostaglandin-F synthase

This is an abbreviated version, for detailed information about prostaglandin-F synthase, go to the full flat file.

Reaction

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate
+
NADP+
=
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
+
NADPH
+
H+

Synonyms

20alpha-HSD/PGFS, 20alpha-hydroxysteroid dehydrogenase/prostaglandin F-synthase, AKR1B1, AKR1B3, AKR1B7, AKR1C3, aldo-keto reductase, aldo-keto reductase 1C3, ALDR1, ALR2, DD1, dihydrodiol dehydrogenase 1, m-PGFS, More, NADPH-dependent prostaglandin D2 11-keto reductase, PG endoperoxide reductase, PGD 11-ketoreductase, PGD2 11-ketoreductase, PGD2 11-ketoreductase activity, PGF synthase, PGF synthase I, PGF synthase II, PGF2alpha synthase, PGF2alpha-synthetic activity, PGFS, PGFS I, PGFS-I, PGFS-II, PGFSI, PGFSII, PGH 9-,11-endoperoxide reductase, PGH2 9,11-endoperoxidase, PGH2 9,11-endoperoxide reductase, PGH2 9-,11-endoperoxide reductase, prostaglandin 11-keto reductase, prostaglandin 11-ketoreductase, prostaglandin D2 11-ketoreductase, prostaglandin D2-ketoreductase, prostaglandin F synthase, prostaglandin F synthase I, prostaglandin F synthase II, prostaglandin F synthetase, prostaglandin F2alpha synthase, prostaglandin F2alpha-synthase, prostaglandin-D2 11-reductase, prostaglandin-F2alpha synthase, prostamide/PGF synthase, prostamide/prostaglandin F synthase, reductase, 15-hydroxy-11-oxoprostaglandin, synthetase, prostaglandin F2alpha, type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase, vas deferens protein

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.188 prostaglandin-F synthase

KM Value

KM Value on EC 1.1.1.188 - prostaglandin-F synthase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.134
(5Z,13E)-(15S)-9alpha,11beta,15-trihydroxyprosta-5,13-dienoate
-
-
0.0119 - 0.013
4-Nitroacetophenone
0.0008 - 0.125
4-Nitrobenzaldehyde
0.0031
5beta-androstan-3,17-dione
-
-
0.001
5beta-Androstan-3alpha-ol-17-one
-
-
0.0175
5beta-dihydrotestosterone
-
; 37°C, liver-type isozyme
0.0001 - 0.002
9,10-phenanthrenequinone
0.0066
androst-4-ene-3,17-dione
-
pH 7.0, 37°C
0.053
cyclohexanone
-
; 37°C, liver-type isozyme
135
D-xylose
-
-
0.143
DL-glyceraldehyde
-
; 37°C, liver-type isozyme
0.0031 - 0.018
Hydrindantin
0.013 - 0.1
menadione
0.0034 - 0.067
NADPH
0.0119
p-nitroacetophenone
-
-
0.02 - 0.08
Phenylglyoxal
0.25
Prostaglandin A2
-
lung enzyme
0.007
prostaglandin D1
-
; 37°C, liver-type isozyme
0.0034 - 2
Prostaglandin D2
0.0056
Prostaglandin D3
-
; 37°C, liver-type isozyme
0.0013 - 0.033
prostaglandin H2
0.015 - 0.18
prostaglandin PGD2
0.003 - 0.03
prostaglandin PGH2
0.02
retinal
-
-
0.0057
testosterone
-
-
additional information
additional information
-
kinetics of 3alpha-hydroxysteroid dehydrogenase type II activity
-