1.1.1.188: prostaglandin-F synthase

This is an abbreviated version, for detailed information about prostaglandin-F synthase, go to the full flat file.

Reaction

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate
+
NADP+
=
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
+
NADPH
+
H+

Synonyms

20alpha-HSD/PGFS, 20alpha-hydroxysteroid dehydrogenase/prostaglandin F-synthase, AKR1B1, AKR1B3, AKR1B7, AKR1C3, aldo-keto reductase, aldo-keto reductase 1C3, ALDR1, ALR2, DD1, dihydrodiol dehydrogenase 1, m-PGFS, More, NADPH-dependent prostaglandin D2 11-keto reductase, PG endoperoxide reductase, PGD 11-ketoreductase, PGD2 11-ketoreductase, PGD2 11-ketoreductase activity, PGF synthase, PGF synthase I, PGF synthase II, PGF2alpha synthase, PGF2alpha-synthetic activity, PGFS, PGFS I, PGFS-I, PGFS-II, PGFSI, PGFSII, PGH 9-,11-endoperoxide reductase, PGH2 9,11-endoperoxidase, PGH2 9,11-endoperoxide reductase, PGH2 9-,11-endoperoxide reductase, prostaglandin 11-keto reductase, prostaglandin 11-ketoreductase, prostaglandin D2 11-ketoreductase, prostaglandin D2-ketoreductase, prostaglandin F synthase, prostaglandin F synthase I, prostaglandin F synthase II, prostaglandin F synthetase, prostaglandin F2alpha synthase, prostaglandin F2alpha-synthase, prostaglandin-D2 11-reductase, prostaglandin-F2alpha synthase, prostamide/PGF synthase, prostamide/prostaglandin F synthase, reductase, 15-hydroxy-11-oxoprostaglandin, synthetase, prostaglandin F2alpha, type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase, vas deferens protein

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.188 prostaglandin-F synthase

Cloned

Cloned on EC 1.1.1.188 - prostaglandin-F synthase

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence analysis, expression analysis in endometrium of cyclic and pregnant animals
expession in Escherichia coli MC1061 or HB101
-
expressed in Escherichia coli BL21 cells
expressed in Escherichia coli HB101 cells; expression Escherichia coli HB101
-
expressed in Escherichia coli HB101 cells; expression in Escherichia coli strain HB101
-
expression in COS-7 cells
-
expression in Escherichia coli
expression in Escherichia coli BL21(DE3)
-
expression in Escherichia coli HB101
-
expression in Escherichia coli strain BL21(DE3) as GST-fusion protein
-
into vector pET-28a and expressed in Escherichia coli BL21 (DE3)
-
into vector pET-28a and expressed in Escherichia coli BL21 (DE3); into vector pET-28a and expressed in Escherichia coli BL21 (DE3)
-
liver-type isozyme, full length cDNA from cDNA library, DNA and amino acid sequence determination and analysis, transient expression of wild-type and mutant enzymes in COS-7 cells
-
overexpression of AKR1C3 using a pLNCX retroviral vector in MCF-7 cell line
-
recombinant enzyme is expressed in Escherichia coli
-
wild-type and mutants, plasmid pCold II-PM/PGFS expressed in Escherichia coli BL21 cells
-