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1.1.1.170: 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)

This is an abbreviated version!
For detailed information about 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating), go to the full flat file.

Word Map on EC 1.1.1.170

Reaction

3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate
+
NAD(P)+
=
4alpha-methyl-5alpha-cholest-7-en-3-one
+
CO2
+
NAD(P)H
+
H+

Synonyms

3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating), 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase, 4alpha-carboxylic acid decarboxylase, C-3 sterol dehydrogenase(C-4 decarboxylase), Erg26, Erg26p, NSDHL, sterol 4alpha-carboxylic decarboxylase, sterol-4-alpha-carboxylate 3-dehydrogenase, sterol-4-alpha-carboxylate-3-dehydrogenase, sterol-4alpha-carboxylate 3-dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.170 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)

Substrates Products

Substrates Products on EC 1.1.1.170 - 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3beta-hydroxy-4alpha-methyl-5alpha-cholest-7-ene-4beta-carboxylate + NAD+
4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH
show the reaction diagram
-
-
-
?
3beta-hydroxy-4beta-methyl-5alpha-cholest-7-en-4alpha-oic acid + NAD+
4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH
show the reaction diagram
-
no epimerization of 4beta-isomer into 4alpha-isomer
-
ir
3beta-hydroxy-cholest-8,24-dien-4alpha-carboxylate + NAD+
4alpha-methyl-cholest-8,24-dien-3-one + CO2 + NADH
show the reaction diagram
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
3-dehydro-4-methylzymosterol + NADPH + CO2
show the reaction diagram
-
-
-
-
?
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NADP+
4alpha-methyl-5alpha-cholesta-8-en-3-one + NADPH + CO2
show the reaction diagram
-
enzyme is involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis
-
-
?
4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
5alpha-cholesta-8,24-dien-3-one + NADPH + CO2
show the reaction diagram
-
-
-
-
?
4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NADP+
5alpha-cholesta-8-en-3-one + CO2 + NADPH
show the reaction diagram
-
enzyme is involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis
-
-
?
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+
a 3-oxosteroid + CO2 + NAD(P)H
show the reaction diagram
additional information
?
-
-
involved in the removal of C-4 methyl groups in postsqualene cholesterol synthesis
-
-
?