1.1.1.170: 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)

This is an abbreviated version, for detailed information about 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating), go to the full flat file.

Reaction

a 3beta-hydroxysteroid-4alpha-carboxylate
+
NAD(P)+
=
a 3-oxosteroid
+
CO2
+
NAD(P)H

Synonyms

3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating), 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase, 4alpha-carboxylic acid decarboxylase, C-3 sterol dehydrogenase(C-4 decarboxylase), NSDHL, sterol 4alpha-carboxylic decarboxylase, sterol-4alpha-carboxylate 3-dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.170 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)

Reference

Reference on EC 1.1.1.170 - 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rahimtula, A.D.; Gaylor, J.L.
Investigation of the component reactions of oxidative sterol demethylation. Partial purification of a microsomal sterol 4alpha-carboxylic acid decarboxylase
J. Biol. Chem.
247
9-15
1972
Rattus sp.
Manually annotated by BRENDA team
Lucas, M.E.; Ma, Q.; Cunningham, D.; Peters, J.; Cattanach, B.; Bard, M.; Elmore, B.K.; Herman, G.E.
Identification of two novel mutations in the murine Nsdhl sterol dehydrogenase gene and development of a functional complementation assay in yeast
Mol. Genet. Metab.
80
227-233
2003
Mus musculus
Manually annotated by BRENDA team
Caldas, H.; Herman, G.E.
NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets
Hum. Mol. Genet.
12
2981-91
2003
Homo sapiens
Manually annotated by BRENDA team
Gachotte, D.; Barbuch, R.; Gaylor, J.; Nickel, E.; Bard, M.
Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis
Proc. Natl. Acad. Sci. USA
95
13794-9
1998
Saccharomyces cerevisiae
Manually annotated by BRENDA team