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1.1.1.170: 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)

This is an abbreviated version!
For detailed information about 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating), go to the full flat file.

Word Map on EC 1.1.1.170

Reaction

3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate
+
NAD(P)+
=
4alpha-methyl-5alpha-cholest-7-en-3-one
+
CO2
+
NAD(P)H
+
H+

Synonyms

3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating), 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase, 4alpha-carboxylic acid decarboxylase, C-3 sterol dehydrogenase(C-4 decarboxylase), Erg26, Erg26p, NSDHL, sterol 4alpha-carboxylic decarboxylase, sterol-4-alpha-carboxylate 3-dehydrogenase, sterol-4-alpha-carboxylate-3-dehydrogenase, sterol-4alpha-carboxylate 3-dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.170 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)

Reference

Reference on EC 1.1.1.170 - 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rahimtula, A.D.; Gaylor, J.L.
Investigation of the component reactions of oxidative sterol demethylation. Partial purification of a microsomal sterol 4alpha-carboxylic acid decarboxylase
J. Biol. Chem.
247
9-15
1972
Rattus sp.
Manually annotated by BRENDA team
Lucas, M.E.; Ma, Q.; Cunningham, D.; Peters, J.; Cattanach, B.; Bard, M.; Elmore, B.K.; Herman, G.E.
Identification of two novel mutations in the murine Nsdhl sterol dehydrogenase gene and development of a functional complementation assay in yeast
Mol. Genet. Metab.
80
227-233
2003
Mus musculus
Manually annotated by BRENDA team
Caldas, H.; Herman, G.E.
NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets
Hum. Mol. Genet.
12
2981-91
2003
Homo sapiens
Manually annotated by BRENDA team
Gachotte, D.; Barbuch, R.; Gaylor, J.; Nickel, E.; Bard, M.
Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis
Proc. Natl. Acad. Sci. USA
95
13794-9
1998
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Bautz, D.J.; Broman, K.W.; Threadgill, D.W.
Identification of a novel polymorphism in X-linked sterol-4-alpha-carboxylate 3-dehydrogenase (Nsdhl) associated with reduced high-density lipoprotein cholesterol levels in I/LnJ mice
G3 (Bethesda)
3
1819-1825
2013
Mus musculus (Q9R1J0)
Manually annotated by BRENDA team
Helliwell, S.B.; Karkare, S.; Bergdoll, M.; Rahier, A.; Leighton-Davis, J.R.; Fioretto, C.; Aust, T.; Filipuzzi, I.; Frederiksen, M.; Gounarides, J.; Hoepfner, D.; Hofmann, A.; Imbert, P.E.; Jeker, R.; Knochenmuss, R.; Krastel, P.; Margerit, A.; Memmert, K.; Miault, C.V.; Movva, N.R.; Muller, A.; Naegeli, H.-U.; Oberer, L.; Prindle, V.; Riedl, R.; Schuierer, S.; Sexton, J.A.; Tao; J.; Wagner, T.; Yin, H.; Zhang, J.; Roggo, S.; Reinker, S.; Parker, C.N.
FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p
Nat. Commun.
6
8613
2015
Candida albicans (Q5A1B0), Homo sapiens (Q15738), Homo sapiens, Saccharomyces cerevisiae (P53199), Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4743 (P53199)
Manually annotated by BRENDA team