1.1.1.153: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

This is an abbreviated version, for detailed information about sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming), go to the full flat file.

Reaction

L-erythro-7,8-dihydrobiopterin
+
NADP+
=
sepiapterin
+
NADPH
+
H+

Synonyms

AKR1B1, reductase, sepiapterin, sepiapterin reductase, SPR, SR

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

Substrates Products

Substrates Products on EC 1.1.1.153 - sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1'-hydroxy-2'-oxopropyltetrahydropterin + NADP+
L-erythro-tetrahydrobiopterin + NADPH
show the reaction diagram
-
-
-
-
1'-hydroxy-2'-oxopropyltetrahydropterin + NADPH
L-erythrotetrahydrobiopterin + NADP+
show the reaction diagram
-
-
-
-
?
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+
D-sepiapterin + NADPH
show the reaction diagram
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH
tetrahydrodictyopterin + NADP+
show the reaction diagram
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
L-sepiapterin + NADPH
show the reaction diagram
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH
L-erythro-tetrahydrobiopterin + NADP+
show the reaction diagram
1,2-cyclohexadione + NADPH
?
show the reaction diagram
-
-
-
-
?
1,2-naphthoquinone + NADPH
?
show the reaction diagram
-
-
-
-
?
1,4-naphthoquinone + NADPH
?
show the reaction diagram
-
-
-
-
?
1-phenyl-1,2-propanedione + NADPH
?
show the reaction diagram
-
-
-
-
?
2,3-butanediol + NADP+
?
show the reaction diagram
-
-
-
-
?
2,3-dimethoxynaphthalene-1,4-dione + NADPH
?
show the reaction diagram
-
-
-
-
?
2,4-pentanedione + NADPH
?
show the reaction diagram
-
-
-
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
show the reaction diagram
6-pyruvoyl tetrahydropterin + NADPH
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
show the reaction diagram
6-pyruvoyl tetrahydropterin + NADPH
L-threo-(6R,1'S,2'S)-5,6,7,8-tetrahydrobiopterin + NADP+
show the reaction diagram
6-pyruvoyl tetrahydropterin + NADPH + H+
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
show the reaction diagram
6-pyruvoyl tetrahydropterin + NADPH + H+
L-threo-(6R,1'S,2'S)-5,6,7,8-tetrahydrobiopterin + NADP+
show the reaction diagram
-
-
-
-
-
6-pyruvoyl tetrahydropterin + NADPH + H+
tetrahydrobiopterin + NADP+
show the reaction diagram
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH
tetrahydrobiopterin + NADP+
show the reaction diagram
6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+
L-erythro-tetrahydrobiopterin + 2 NADP+
show the reaction diagram
6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+
L-threo-tetrahydrobiopterin + 2 NADP+
show the reaction diagram
6-pyruvoyltetrahydropterin + NADPH
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
show the reaction diagram
-
-
no synthesis of the D-isomer
-
?
9,10-phenanthrenequinone + NADP+
?
show the reaction diagram
-
-
-
-
?
9,10-phenanthrenequinone + NADPH
?
show the reaction diagram
-
-
-
-
?
acetohexamide + NADPH
?
show the reaction diagram
-
-
-
-
?
acetoin + NADPH
?
show the reaction diagram
acetophenone + NADPH
?
show the reaction diagram
-
-
-
-
?
benzil + NADPH
?
show the reaction diagram
benzylacetone + NADPH
?
show the reaction diagram
-
-
-
-
?
diacetyl + NADPH
?
show the reaction diagram
diacetyl + NADPH
acetoin + NADP+
show the reaction diagram
-
NADPH-dependent dicarbonyl reductase activity
-
-
?
dihydrotepidopterin + NADP+
?
show the reaction diagram
-
15% relative activity
-
-
?
isosepiapterin + NADPH
6-(1-hydroxypropyl)-dihydropterin + NADP+
show the reaction diagram
-
-
-
?
isosepiapterin + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
L-erythro-dihydrobiopterin + NADP+
?
show the reaction diagram
-
-
-
-
?
L-erythro-dihydroneopterin + NADP+
?
show the reaction diagram
L-threo-dihydrobiopterin + NADP+
?
show the reaction diagram
-
D-isomer 45% relative activity
-
-
r
L-threo-dihydroneopterin + NADP+
?
show the reaction diagram
lactoyltetrahydropterin + NADPH
L-erythrotetrahydrobiopterin + NADP+
show the reaction diagram
-
-
-
-
?
lactoyltetrahydropterin + NADPH + H+
L-erythro-tetrahydrobiopterin + NADP+
show the reaction diagram
-
-
-
-
menadione + NADPH
?
show the reaction diagram
methylglyoxal + NADPH
?
show the reaction diagram
p-nitrobenzaldehyde + NADPH
p-nitrobenzyl alcohol + NADP+
show the reaction diagram
p-quinone + NADPH
?
show the reaction diagram
-
-
-
-
?
phenylglyoxal + NADPH
?
show the reaction diagram
phenylpropanedione + NADPH
phenylpropan-2,3-diol + NADP+
show the reaction diagram
-
NADPH-dependent dicarbonyl reductase activity
-
-
?
propiophenone + NADPH
?
show the reaction diagram
-
-
-
-
?
pyruvoyltetrahydropterin + NADPH
L-erythrotetrahydrobiopterin + NADP+
show the reaction diagram
-
-
-
-
?
sepiapterin + NADPH
1'-hydroxy-2'-oxopropyltetrahydropterin + NADP+
show the reaction diagram
-
best substrate
-
-
?
sepiapterin + NADPH
7,8-dihydrobiopterin + NADP+
show the reaction diagram
-
-
-
-
?
sepiapterin + NADPH + H+
7,8-dihydrobiopterin + NADP+
show the reaction diagram
xanthopterin B2 + NADPH
6-(1',2'-dihydroxypropyl)-dihydrolumazine + NADP+
show the reaction diagram
-
-
-
?
xanthopterin-B2 + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
additional information
?
-