1.1.1.153: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

This is an abbreviated version, for detailed information about sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming), go to the full flat file.

Reaction

L-erythro-7,8-dihydrobiopterin
+
NADP+
=
sepiapterin
+
NADPH
+
H+

Synonyms

AKR1B1, reductase, sepiapterin, sepiapterin reductase, SPR, SR

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

Storage Stability

Storage Stability on EC 1.1.1.153 - sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-15C, in 150 mM Tris-HCl buffer, pH 6.0, second hydroxylapatite fraction, for 1 week, relatively little loss of activity
-
-15C, purified enzyme, 0.01 M potassium phosphate buffer, pH 6.0, stable for 1 week with little loss of activity
-
-40C, in 50 mM potassium phosphate buffer, pH 6.9, at least stable for two months
-
-70C, after dialyzation against Pipes, pH 7.5, 10% glycerol
-
-70C, desalted extracts, several weeks without significant loss of activity
-
-70C, in 20 mM Tris-HCl, pH 8.8
-
-80C, in 50 mM potassium phosphate buffer, 0,1 M KCl, pH 6.8
-
20C, after ion exchange chromatography, no change in activity over one year of storage
-