1.1.1.153: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

This is an abbreviated version, for detailed information about sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming), go to the full flat file.

Reaction

L-erythro-7,8-dihydrobiopterin
+
NADP+
=
sepiapterin
+
NADPH
+
H+

Synonyms

AKR1B1, reductase, sepiapterin, sepiapterin reductase, SPR, SR

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.153 sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

Reference

Reference on EC 1.1.1.153 - sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Citron, B.A.; Milstien, S.; Gutierrez, J.C.; Levine, R.A.; Yanak, B.L.; Kaufman, S.
Isolation and expression of rat liver sepiapterin reductase cDNA
Proc. Natl. Acad. Sci. USA
87
6436-6440
1990
Rattus norvegicus
Manually annotated by BRENDA team
Nagai, M.
Studies on sepiapterin reductase: further characterization of the reaction product
Arch. Biochem. Biophys.
126
426-435
1968
Rattus norvegicus
Manually annotated by BRENDA team
Matsubara, M.; Katoh, S.; Akino, M.; Kaufman, S.
Sepiapterin reductase
Biochim. Biophys. Acta
122
202-212
1966
Rattus norvegicus
Manually annotated by BRENDA team
Katoh, S.
Sepiapterin reductase from horse liver: purification and properties of the enzyme
Arch. Biochem. Biophys.
146
202-214
1971
Equus caballus, Rattus norvegicus
Manually annotated by BRENDA team
Katoh, S.; Arai, Y.; Taketani, T.; Yamada, S.
Sepiapterin reductase in blood of various animals and of leukemic rats
Biochim. Biophys. Acta
370
378-388
1974
Canis lupus familiaris, Cavia porcellus, Gallus gallus, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus, Rattus norvegicus Donryu, Rattus norvegicus Sprague-Dawley, Sus scrofa
Manually annotated by BRENDA team
Sueoka, T.; Katoh, S.
Purification and characterization of sepiapterin reductase from rat erythrocytes
Biochim. Biophys. Acta
717
265-271
1982
Rattus norvegicus
Manually annotated by BRENDA team
Fere, J.; Naylor, E.W.
Sepiapterin reductase in cultured human cells
Biochem. Biophys. Res. Commun.
148
1475-1481
1987
Homo sapiens
Manually annotated by BRENDA team
Werner, E.R.; Werner-Felmayer, G.; Fuchs, D.; Hausen, A.; Reibnegger, G.; Yim, J.J.; Pfleiderer, W.; Wachter, H.
Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T 24 cells. GTP-cyclohydrolase I is stimulated by interferon-gamma, and 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase are constitutively present
J. Biol. Chem.
265
3189-3192
1990
Drosophila melanogaster, Drosophila melanogaster Oregon R, Homo sapiens
Manually annotated by BRENDA team
Kerler, F.; Hultner, L.; Ziegler, I.; Katzenmaier, G.; Bacher, A.
Analysis of the tetrahydrobiopterin synthesizing system during maturation of murine reticulocytes
J. Cell. Physiol.
142
268-271
1990
Mus musculus
Manually annotated by BRENDA team
Katoh, S.; Sueoka, T.
Isomerization of 6-lactoyl tetrahydropterin by sepiapterin reductase
J. Biochem.
101
275-278
1987
Rattus norvegicus
Manually annotated by BRENDA team
Katoh, S.; Sueoka, T.
Sepiapterin reductase exhibits a NADPH-dependent dicarbonyl reductase activity
Biochem. Biophys. Res. Commun.
118
859-866
1984
Rattus norvegicus
Manually annotated by BRENDA team
Sueoka, T.; Katoh, S.
Carbonyl reductase activity of sepiapterin reductase from rat erythrocytes
Biochim. Biophys. Acta
843
193-198
1985
Rattus norvegicus
Manually annotated by BRENDA team
Curtius, H.C.; Heintel, D.; Ghisla, S.; Kuster, T.; Leimbacher, W.; Niederwieser, A.
Tetrahydrobiopterin biosynthesis. Studies with specifically labeled (2H)NAD(P)H and 2H2O and of the enzymes involved
Eur. J. Biochem.
148
413-419
1985
Homo sapiens
Manually annotated by BRENDA team
Katoh, S.; Sueoka, T.; Yamada, S.
Direct inhibition of brain sepiapterin reductase by a catecholamine and an indoleamine
Biochem. Biophys. Res. Commun.
105
75-81
1982
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Smith, G.K.
On the role of sepiapterin reductase in the biosynthesis of tetrahydrobiopterin
Arch. Biochem. Biophys.
255
254-266
1987
Rattus norvegicus
Manually annotated by BRENDA team
Maier, J.; Ziegler, I.
Purification and properties of human sepiapterin reductase from placenta
Adv. Exp. Med. Biol.
338
199-202
1993
Homo sapiens
Manually annotated by BRENDA team
Cho, S.H.; Na, J.U.; Youn, H.; Hwang, C.S.; Lee, C.H.; Kang, S.O.
Sepiapterin reductase producing L-threo-dihydrobiopterin from Chlorobium tepidum
Biochem. J.
340
497-503
1999
Chlorobaculum tepidum
-
Manually annotated by BRENDA team
Smith, G.K.; Duch, D.S.; Edelstein, M.P.; Bigham, E.C.
New inhibitors of sepiapterin reductase
J. Biol. Chem.
267
5599-5607
1992
Bos taurus
Manually annotated by BRENDA team
Fujimoto, K.; Hara, M.; Yamada, H.; Sakurai, M.; Inaba, A.; Tomomura, A.; Katoh, S.
Role of the conserved Ser-Tyr-Lys triad of the SDR family in sepiapterin reductase
Chem. Biol. Interact.
130-132
825-832
2001
Rattus norvegicus
Manually annotated by BRENDA team
Ruiz-Vazquez, P.; Silva, F.J.; Ferre, J.
Characterization of sepiapterin reductase activity from Drosophila melanogaster
Comp. Biochem. Physiol. B
113
131-136
1996
Drosophila melanogaster, Drosophila melanogaster Oregon R
Manually annotated by BRENDA team
Kim, Y.A.; Chung, H.J.; Kim, Y.J.; Choi, Y.K.; Hwang, Y.K.; Lee, S.W.; Park, Y.S.
Characterization of recombinant Dictyostelium discoideum sepiapterin reductase expressed in E. coli
Mol. Cells
10
405-410
2000
Dictyostelium discoideum, Phycomyces sp.
Manually annotated by BRENDA team
Yoon, K.H.; Cha, K.W.; Park, S.I.; Yim, J.J.
Isolation and characterization of sepiapterin reductase from Drosophila melanogaster
Pteridines
4
43-50
1993
Drosophila melanogaster, Drosophila melanogaster Oregon R
-
Manually annotated by BRENDA team
Auerbach, G.; Herrmann, A.; Gutlich, M.; Fischer, M.; Jacob, U.; Bacher, A.; Huber, R.
The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters
EMBO J.
16
7219-7230
1997
Mus musculus, Mus musculus (Q64105)
Manually annotated by BRENDA team
Dowling, T.G.; O'Rourke, J.F.; Tipton, K.F.
Sepiapterin reductase and ALR2 ('aldose reductase') from bovine brain
Adv. Exp. Med. Biol.
328
313-324
1993
Bos taurus
Manually annotated by BRENDA team
Ikemoto, K.; Suzuki, T.; Ichinose, H.; Ohye, T.; Nishimura, A.; Nishi, K.; Nagatsu, I.; Nagatsu, T.
Localization of sepiapterin reductase in the human brain
Brain Res.
954
237-246
2002
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Fujimoto, K.; Sakurai, M.; Kawase, M.; Katoh, S.
Effect of antisense oligodeoxynucleotide for sepiapterin reductase on the viability of PC12 cells in the presence of exogenous carbonyl compounds
Chem. Biol. Interact.
143-144
583-586
2003
Rattus norvegicus
Manually annotated by BRENDA team
Choi, Y.K.; Jun, S.R.; Cha, E.Y.; Park, J.S.; Park, Y.S.
Sepiapterin reductases from Chlorobium tepidum and Chlorobium limicola catalyze the synthesis of L-threo-tetrahydrobiopterin from 6-pyruvoyltetrahydropterin
FEMS Microbiol. Lett.
242
95-99
2005
Chlorobaculum tepidum, Chlorobium limicola, Chlorobium limicola (Q5XPX7)
Manually annotated by BRENDA team
Negishi, S.; Fujimoto, K.; Katoh, S.
Localization of sepiapterin reductase in pigment cells of Oryzias latipes
Pigment Cell Res.
16
501-503
2003
Oryzias latipes, Rattus norvegicus
Manually annotated by BRENDA team
Supangat, S.; Choi, Y.K.; Park, Y.S.; Son, D.; Han, C.D.; Lee, K.H.
Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum
Acta Crystallogr. Sect. F
61
202-204
2005
Chlorobaculum tepidum
Manually annotated by BRENDA team
Nagai, M.
Studies on sepiapterin reductase: further characterization of the reaction product
Arch. Biochem. Biophys.
126
420-435
1968
Rattus norvegicus
-
Manually annotated by BRENDA team
Choi, Y.K.; Kong, J.S.; Park, Y.S.
Functional role of sepiapterin reductase in the biosynthesis of tetrahydropteridines in Dictyostelium discoideum Ax2
Biochim. Biophys. Acta
1760
877-882
2006
Dictyostelium discoideum, Dictyostelium discoideum AX2
Manually annotated by BRENDA team
Choi, Y.K.; Park, J.S.; Kong, J.S.; Morio, T.; Park, Y.S.
D-threo-tetrahydrobiopterin is synthesized via 1-oxo-2-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum Ax2
FEBS Lett.
579
3085-3089
2005
Dictyostelium discoideum, Dictyostelium discoideum AX2
Manually annotated by BRENDA team
Thoeny, B.; Blau, N.
Mutations in the BH4-metabolizing genes GTP cyclohydrolase I, 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase, carbinolamine-4a-dehydratase, and dihydropteridine reductase
Hum. Mutat.
27
870-878
2006
Homo sapiens
Manually annotated by BRENDA team
Supangat, S.; Seo, K.H.; Choi, Y.K.; Park, Y.S.; Son, D.; Han, C.D.; Lee, K.H.
Structure of Chlorobium tepidum sepiapterin reductase complex reveals the novel substrate binding mode for stereospecific production of L-threo-tetrahydrobiopterin
J. Biol. Chem.
281
2249-2256
2006
Chlorobaculum tepidum
Manually annotated by BRENDA team
Takazawa, C.; Fujimoto, K.; Homma, D.; Sumi-Ichinose, C.; Nomura, T.; Ichinose, H.; Katoh, S.
A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice - as a mouse model for Parkinsons disease
Biochem. Biophys. Res. Commun.
367
787-792
2008
Mus musculus
Manually annotated by BRENDA team
Tobin, J.E.; Cui, J.; Wilk, J.B.; Latourelle, J.C.; Laramie, J.M.; McKee, A.C.; Guttman, M.; Karamohamed, S.; DeStefano, A.L.; Myers, R.H.
Sepiapterin reductase expression is increased in Parkinsons disease brain tissue
Brain Res.
1139
42-47
2007
Homo sapiens
Manually annotated by BRENDA team
Widder, J.D.; Chen, W.; Li, L.; Dikalov, S.; Thoeny, B.; Hatakeyama, K.; Harrison, D.G.
Regulation of tetrahydrobiopterin biosynthesis by shear stress
Circ. Res.
101
830-838
2007
Homo sapiens
Manually annotated by BRENDA team
Kim, H.L.; Choi, Y.K.; Kim, d.o..H.; Park, S.O.; Han, J.; Park, Y.S.
Tetrahydropteridine deficiency impairs mitochondrial function in Dictyostelium discoideum Ax2
FEBS Lett.
581
5430-5434
2007
Dictyostelium discoideum
Manually annotated by BRENDA team
Sawabe, K.; Yamamoto, K.; Harada, Y.; Ohashi, A.; Sugawara, Y.; Matsuoka, H.; Hasegawa, H.
Cellular uptake of sepiapterin and push-pull accumulation of tetrahydrobiopterin
Mol. Genet. Metab.
94
410-416
2008
Homo sapiens
Manually annotated by BRENDA team
Supangat, S.; Park, S.O.; Seo, K.H.; Lee, S.Y.; Park, Y.S.; Lee, K.H.
Role of Phe-99 and Trp-196 of sepiapterin reductase from Chlorobium tepidum in the production of L-threo-tetrahydrobiopterin
Acta Biochim. Biophys. Sin. (Shanghai)
40
513-518
2008
Chlorobaculum tepidum
Manually annotated by BRENDA team
Gao, L.; Pung, Y.F.; Zhang, J.; Chen, P.; Wang, T.; Li, M.; Meza, M.; Toro, L.; Cai, H.
Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability
Am. J. Physiol. Heart Circ. Physiol.
297
H331-H339
2009
Bos taurus, Bos taurus (Q17QK8)
Manually annotated by BRENDA team
Hirakawa, H.; Sawada, H.; Yamahama, Y.; Takikawa, S.; Shintaku, H.; Hara, A.; Mase, K.; Kondo, T.; Iino, T.
Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues
J. Biochem.
146
51-60
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Meng, Y.; Katsuma, S.; Daimon, T.; Banno, Y.; Uchino, K.; Sezutsu, H.; Tamura, T.; Mita, K.; Shimada, T.
The silkworm mutant lemon (lemon lethal) is a potential insect model for human sepiapterin reductase deficiency
J. Biol. Chem.
284
11698-11705
2009
Bombyx mori
Manually annotated by BRENDA team
McHugh, P.C.; Joyce, P.R.; Kennedy, M.R.
Polymorphisms of sepiapterin reductase gene alter promoter activity and may influence risk of bipolar disorder
Pharmacogenet. Genomics
19
330-337
2009
Homo sapiens
Manually annotated by BRENDA team
Yang, S.; Jan, Y.H.; Gray, J.P.; Mishin, V.; Heck, D.E.; Laskin, D.L.; Laskin, J.D.
Sepiapterin Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells
J. Biol. Chem.
288
19221-19237
2013
Homo sapiens
Manually annotated by BRENDA team